Evidence map›Paper›PMID 36614033›Full record

ArticleInternational journal of molecular sciences2022

Interaction between Nanoparticles, Membranes and Proteins: A Surface Plasmon Resonance Study.

Erenildo Ferreira de Macedo, Nivia Salles Santos, Lucca Silva Nascimento, Raphaël Mathey, Sophie Brenet, Matheus Sacilotto de Moura, Yanxia Hou, Dayane Batista Tada

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Nanomaterials (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Annatto (Pharmaceutics · 2024
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Erenildo Ferreira de MacedoLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo (UNIFESP), São José dos Campos 12231280, SP, Brazil.
Nivia Salles SantosLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo (UNIFESP), São José dos Campos 12231280, SP, Brazil.
Lucca Silva NascimentoLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo (UNIFESP), São José dos Campos 12231280, SP, Brazil.
Raphaël MatheyUniversity Grenoble Alpes, CEA, CNRS, IRIG-SYMMES, 38000 Grenoble, France.ORCID 0000-0002-2737-2192
Sophie BrenetUniversity Grenoble Alpes, CEA, CNRS, IRIG-SYMMES, 38000 Grenoble, France.
Matheus Sacilotto de MouraLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo (UNIFESP), São José dos Campos 12231280, SP, Brazil.
Yanxia HouUniversity Grenoble Alpes, CEA, CNRS, IRIG-SYMMES, 38000 Grenoble, France.ORCID 0000-0002-2991-1030
Dayane Batista TadaLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo (UNIFESP), São José dos Campos 12231280, SP, Brazil.
Centre National de la Recherche Scientifique · FRUniversidade Federal de São Paulo · BR

Funding

São Paulo Research Foundation 2020/00807-5; 2019/06803-4; 2016/20503-5; 2016/14795-3, 2016/07354-0, 2017/01697-6
6 · The paper itself

Abstract

Regardless of the promising use of nanoparticles (NPs) in biomedical applications, several toxic effects have increased the concerns about the safety of these nanomaterials. Although the pathways for NPs toxicity are diverse and dependent upon many parameters such as the nature of the nanoparticle and the biochemical environment, numerous studies have provided evidence that direct contact between NPs and biomolecules or cell membranes leads to cell inactivation or damage and may be a primary mechanism for cytotoxicity. In such a context, this work focused on developing a fast and accurate method to characterize the interaction between NPs, proteins and lipidic membranes by surface plasmon resonance imaging (SPRi) technique. The interaction of gold NPs with mimetic membranes was evaluated by monitoring the variation of reflectivity after several consecutive gold NPs injections on the lipidic membranes prepared on the SPRi biochip. The interaction on the membranes with varied lipidic composition was compared regarding the total surface concentration density of gold NPs adsorbed on them. Then, the interaction of gold and silver NPs with blood proteins was analyzed regarding their kinetic profile of the association/dissociation and dissociation constants (k

Indexed as

Metal NanoparticlesNanoparticlesGoldProteinsSilverSurface Plasmon Resonancecolloidal silverGoldProteinsSilveraffinitybiomolecular interactionsblood serum proteinsmembranesnanocomplex dissociation ratenanoparticlesprotein coronasurface plasmon resonance imaging

Identifiers

PMID36614033
PMCPMC9820549
OpenAlexW4313361966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.