SynthesisInternational journal of molecular sciences2022
Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis.
Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Association Between Serum Leptin Concentrations and Disease Severity Across Airway Disease Phenotypes: A Single-Center Retrospective Observational Study.Diseases (Basel, Switzerland) · 2026Article
- Leptin-induced autophagy regulates the immunomodulatory potential of adipose-derived mesenchymal stem cells through down regulating the expression of TSG-6.Scientific reports · 2026Article
- A Multi-Omics Approach Uncovers Divergent Mechanisms of Asthma in Normal Weight and Obese Children.Metabolites · 2026Article
- A Body Shape Index and asthma prevalence in Chinese middle-aged and older adults: a cross-sectional study.BMC pulmonary medicine · 2026Article
- Mechanistic advances in the regulation of asthma by different exercise modalities: an integrative perspective on exercise load characteristics and asthma heterogeneity.Frontiers in physiology · 2026Review
- The mechanistic role of adipokine imbalance in airway inflammation, hyperresponsiveness, and remodeling in obesity-related asthma.Frontiers in endocrinology · 2026Review
- Obesity and weight change during eight years in relation to asthma incidence.Scientific reports · 2025Article
- Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan.Archives of Razi Institute · 2025Article
- High Interleukin (IL)-6 is Associated with Lower Lung Function and Increased Likelihood of Metabolic Dysfunction in Asthma.Pulmonary therapy · 2025Article
- Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness.JCI insight · 2025Article
- Association of BMI trajectories and healthy aging among Chinese older adults: a national cohort study.Frontiers in public health · 2025Article
- Euiin-Tang Attenuates Obesity-Induced Asthma by Resolving Metaflammation.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing in Children.Children (Basel, Switzerland) · 2024Review
- The Role of Peptides in Asthma-Obesity Phenotype.International journal of molecular sciences · 2024Review
- TRP channels associated with macrophages as targets for the treatment of obese asthma.Lipids in health and disease · 2024Review
- The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.Biomedicines · 2023Article
- Effect of Obesity on Lung Function in the Pediatric and Adult Populations with Asthma: A Review.Journal of clinical medicine · 2023Review
- Herbal medicine for the treatment of obesity-associated asthma: a comprehensive review.Frontiers in pharmacology · 2023Review
- Progress in diagnosis and treatment of difficult-to-treat asthma in children.Therapeutic advances in respiratory diseaseReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma. Adipose tissue secretes proinflammatory cytokines and mediators, including leptin, which may promote the development and severity of asthma in obese patients. This study is a systematic review and a meta-analysis based on the relationship between leptin and asthma during obesity. MEDLINE, Cochrane, EMBASE and CINAHL databases were used. Data heterogeneity was analyzed using Cochran’s Q and treatment effect with the DerSimonian and Laird method. Random effect analyses were carried out to test data sensitivity. Asymmetry was estimated using Begg’s and Egger’s tests. All studies showed significant differences in leptin levels. The effect of the measures (p < 0.001), data sensitivity (p < 0.05) and data asymmetry were statistically significant, as well as tBegg’s test (p = 0.010) and Egge’s test (p < 0.001). Despite the existing limiting factors, the results of this study support the relevant role of leptin in the pathophysiology of asthma in obese subjects. Nevertheless, further studies are needed to obtain better insight in the relationship between leptin and asthma in obesity.
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