Evidence map›Paper›PMID 36613976›Full record

ArticleInternational journal of molecular sciences2022

In Vitro Study of the Blood-Brain Barrier Transport of Natural Compounds Recovered from Agrifood By-Products and Microalgae.

José David Sánchez-Martínez, Ana Rita Garcia, Gerardo Alvarez-Rivera, Alberto Valdés, Maria Alexandra Brito, Alejandro Cifuentes

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Evaluation of the In Vitro Blood-Brain Barrier Transport ofInternational journal of molecular sciences · 2025
    Article
  3. Neuroprotective Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

José David Sánchez-MartínezLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0003-3134-5960
Ana Rita GarciaResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Gerardo Alvarez-RiveraLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0003-1657-8141
Alberto ValdésLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7901-5816
Maria Alexandra BritoResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.ORCID 0000-0002-8493-4649
Alejandro CifuentesLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7464-0217

Funding

Ministry of Science and Innovation of Spain Grant No. PID2020-113050RB-I00 and Grant No. PDC2021-120814-I00
6 · The paper itself

Abstract

Agrifood by-products and microalgae represent a low-cost and valuable source of bioactive compounds with neuroprotective properties. However, the neuroprotective effectiveness of therapeutic molecules can be limited by their capacity to cross the blood-brain barrier (BBB) and reach the brain. In this research, various green extracts from

Indexed as

Blood-Brain BarrierMicroalgaeBrainEndothelial CellsGas Chromatography-Mass SpectrometryHumansbioactive compoundsblood–brain barrierfood wastegreen-extractionLC/GC-q-TOF-MSneuroprotection

Identifiers

PMID36613976
PMCPMC9820279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.