Evidence map›Paper›PMID 36613961›Full record

ArticleInternational journal of molecular sciences2022

Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations.

Stefan Schwerin, Catharina Westphal, Claudia Klug, Gerhard Schneider, Matthias Kreuzer, Rainer Haseneder, Stephan Kratzer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stefan SchwerinDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Catharina WestphalDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Claudia KlugDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Gerhard SchneiderDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.ORCID 0000-0002-4903-0118
Matthias KreuzerDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Rainer HasenederDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Stephan KratzerDepartment of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
TUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine is a selective α

Indexed as

DexmedetomidineHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAdrenergic alpha-2 Receptor AgonistsAnimalsCyclic Nucleotide-Gated Cation ChannelsHypnotics and SedativesMiceThalamusAdrenergic alpha-2 Receptor AgonistsCyclic Nucleotide-Gated Cation ChannelsDexmedetomidineHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsHypnotics and Sedativesanesthesiadexmedetomidinehcn channelpatch-clampthalamocortical relay neuronthalamus

Identifiers

PMID36613961
PMCPMC9820684
OpenAlexW4313327999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.