Evidence map›Paper›PMID 36613935›Full record

ArticleInternational journal of molecular sciences2022

The

Kenneth Chappell, Romain Colle, Jérôme Bouligand, Séverine Trabado, Bruno Fève, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Sex-specific Serum Biomarker Associations with Antidepressant Treatment Outcomes in Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kenneth ChappellCESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Université Paris-Saclay, F-94275 Le Kremlin Bicêtre, France.
Romain ColleCESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Université Paris-Saclay, F-94275 Le Kremlin Bicêtre, France.
Jérôme BouligandService de Génétique Moléculaire, Pharmacogénétique et Hormonologie de Bicêtre, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, F-94275 Le Kremlin Bicêtre, France.
Séverine TrabadoService de Génétique Moléculaire, Pharmacogénétique et Hormonologie de Bicêtre, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, F-94275 Le Kremlin Bicêtre, France.
Bruno FèveCentre de Recherche Saint-Antoine, Institut Hospitalo-Universitaire ICAN, Service d'Endocrinologie, CRMR PRISIS, Sorbonne Université-INSERM, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, F-75012 Paris, France.ORCID 0000-0001-6577-9009
Laurent BecquemontCESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Université Paris-Saclay, F-94275 Le Kremlin Bicêtre, France.
Emmanuelle CorrubleCESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Université Paris-Saclay, F-94275 Le Kremlin Bicêtre, France.
Céline VerstuyftCESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Université Paris-Saclay, F-94275 Le Kremlin Bicêtre, France.ORCID 0000-0002-8534-224X
Inserm · FRAssistance Publique – Hôpitaux de Paris · FR

Funding

Programme Hospitalier de Recherche Publique (PHRC) AOM06022
6 · The paper itself

Abstract

Major depressive disorder (MDD) is the leading cause of disability worldwide. Treatment with antidepressant drugs (ATD), which target monoamine neurotransmitters including serotonin (5HT), are only modestly effective. Monoamine oxidase (MAO) metabolizes 5HT to 5-hydroxy indoleacetic acid (5HIAA). Genetic variants in the X-chromosome-linked MAO-encoding genes,

Indexed as

Major Depressive DisorderMonoamine OxidaseAntidepressive AgentsBiomarkersFemaleHumansMalePolymorphism, GeneticAntidepressive AgentsBiomarkersMonoamine Oxidasemonoamine oxidase A, humanantidepressant drugsmajor depressive disorderMAOpharmacogeneticsserotonin

Identifiers

PMID36613935
PMCPMC9820795
OpenAlexW4313413311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.