Evidence map›Paper›PMID 36613875›Full record

ArticleInternational journal of molecular sciences2022

Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D

Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Michelle Taylor, Robert R Luedtke, Robert H Mach

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Novel Scaffold Agonists of the αMolecules (Basel, Switzerland) · 2024
    Article
  6. Frontiers in neuroscience · 2024
    Article
  7. Design and Synthesis of DMolecules (Basel, Switzerland) · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ho Young KimVagelos Laboratories, Department of Radiology, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, PA 19104, USA.ORCID 0000-0003-4391-9642
Ji Youn LeeVagelos Laboratories, Department of Radiology, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, PA 19104, USA.
Chia-Ju HsiehVagelos Laboratories, Department of Radiology, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-2833-7727
Michelle TaylorDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Robert R LuedtkeDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Robert H MachVagelos Laboratories, Department of Radiology, University of Pennsylvania, 1012, 231 S. 34th Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-7645-2869
University of Pennsylvania · USUniversity of North Texas · US

Funding

PET RADIOTRACERS FOR IMAGING THE DOPAMINE D3 RECEPTORR01DA029840 · NIDA · WASHINGTON UNIVERSITY · PI MACH, ROBERT H · 2010 to 2020
$4.3M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NIDA NIH HHS DA029840NIDA NIH HHS R01 DA029840NIH HHS S10 OD023495
6 · The paper itself

Abstract

Previous studies have confirmed that the binding of D

Indexed as

Receptors, Dopamine D2Receptors, Dopamine D3BenzamidesDopamineLigandsStructure-Activity RelationshipbenzamideBenzamidesDopamineLigandsReceptors, Dopamine D2Receptors, Dopamine D3bitopic ligandcomputational chemistryD3 receptor antagonistsmetoclopramideβ-arrestin recruitment assay

Identifiers

PMID36613875
PMCPMC9820167
OpenAlexW4313259815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.