Evidence map›Paper›PMID 36613739›Full record

ArticleInternational journal of molecular sciences2022

L-Carnitine Functionalization to Increase Skeletal Muscle Tropism of PLGA Nanoparticles.

Ilaria Andreana, Manuela Malatesta, Maria Assunta Lacavalla, Federico Boschi, Paola Milla, Valeria Bincoletto, Carlo Pellicciari, Silvia Arpicco, Barbara Stella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ilaria AndreanaDepartment of Drug Science and Technology, University of Torino, I-10125 Torino, Italy.ORCID 0000-0001-9457-3667
Manuela MalatestaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, I-37134 Verona, Italy.ORCID 0000-0001-8196-9232
Maria Assunta LacavallaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, I-37134 Verona, Italy.ORCID 0000-0002-6421-4257
Federico BoschiDepartment of Computer Science, University of Verona, I-37134 Verona, Italy.ORCID 0000-0001-9623-6859
Paola MillaDepartment of Drug Science and Technology, University of Torino, I-10125 Torino, Italy.ORCID 0000-0002-4245-4161
Valeria BincolettoDepartment of Drug Science and Technology, University of Torino, I-10125 Torino, Italy.
Carlo PellicciariDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, I-27100 Pavia, Italy.ORCID 0000-0001-7684-0469
Silvia ArpiccoDepartment of Drug Science and Technology, University of Torino, I-10125 Torino, Italy.
Barbara StellaDepartment of Drug Science and Technology, University of Torino, I-10125 Torino, Italy.ORCID 0000-0001-8266-6604
University of Turin · ITUniversity of Verona · ITUniversity of Pavia · IT

Funding

University of Turin Fondi Ricerca Locale (ex-60%)
6 · The paper itself

Abstract

Muscular dystrophies are a group of rare genetic pathologies, encompassing a variety of clinical phenotypes and mechanisms of disease. Several compounds have been proposed to treat compromised muscles, but it is known that pharmacokinetics and pharmacodynamics problems could occur. To solve these issues, it has been suggested that nanocarriers could be used to allow controlled and targeted drug release. Therefore, the aim of this study was to prepare actively targeted poly(lactide-

Indexed as

CarnitineNanoparticlesBiological TransportDrug CarriersMuscle Fibers, SkeletalCarnitineDrug Carriersactive targetingfluorescence microscopyL-carnitinenanoparticlesPLGAskeletal muscle cellstransmission electron microscopy

Identifiers

PMID36613739
PMCPMC9820419
OpenAlexW4313245879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.