Evidence map›Paper›PMID 36613725›Full record

ArticleInternational journal of molecular sciences2022

Childhood Hypophosphatasia Associated with a Novel Biallelic

Luciane Martins, Luis Gustavo F Lessa, Taccyanna M Ali, Monize Lazar, Chong A Kim, Kamila R Kantovitz, Mauro P Santamaria, Cássia F Araújo, Carolina J Ramos, Brian L Foster and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Multidimensional nomogram for prediction of cardiovascular disease risk in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  2. Article
  3. New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Luciane MartinsDepartment of Community Medicine and Epidemiology, CHS National Cancer Control Center, Haifa 3436212, Israel.ORCID 0000-0003-3635-7928
Luis Gustavo F LessaDepartment of Research, São Leopoldo Mandic School of Dentistry and Research Center, Campinas, São Paulo 13045-755, Brazil.
Taccyanna M AliCentro de Estudos do Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Monize LazarCentro de Estudos do Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Chong A KimClinical Genetics, Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil.
Kamila R KantovitzDepartment of Biomaterials, São Leopoldo Mandic School of Dentistry and Research Center, Campinas, São Paulo 13045-755, Brazil.
Mauro P SantamariaCenter for Oral Health Research, University of Kentucky, College of Dentistry, Lexington, KY 40536, USA.ORCID 0000-0001-9468-0729
Cássia F AraújoDepartment of Diagnosis and Surgery, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil.ORCID 0000-0002-8918-5472
Carolina J RamosDepartment of Diagnosis and Surgery, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil.
Brian L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.
José Francisco S FrancoCenter of Research and Molecular Diagnosis of Genetic Diseases, Department of Biophysics, UNIFESP and Biotecnologic Centre, Energy and Nuclear Research Institute (IPEN), Universidade de São Paulo, São Paulo 05508-000, Brazil.
Débora BertolaCentro de Estudos do Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Francisco H NocitiDepartment of Research, São Leopoldo Mandic School of Dentistry and Research Center, Campinas, São Paulo 13045-755, Brazil.ORCID 0000-0001-6809-8866
Universidade de São Paulo · BRFaculdade São Leopoldo Mandic · BRUniversidade Estadual Paulista (Unesp) · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRThe Ohio State University · USUniversity of Kentucky · US

Funding

Role of tissue-nonspecific alkaline phosphatase in dentoalveolar development and diseaseR03DE028411 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$312k
NIDCR NIH HHS R03 DE028411
6 · The paper itself

Abstract

The goal of this study was to perform a clinical and molecular investigation in an eight-year-old female child diagnosed with hypophosphatasia (HPP). The proband and her family were evaluated by medical and dental histories, biochemical analyses, radiographic imaging, and genetic analysis of the tissue-nonspecific alkaline phosphatase (

Indexed as

Alkaline PhosphataseHypophosphatasiaChildFemaleHumansMutation, MissenseAlkaline PhosphataseALPL protein, human3D modelingalkaline phosphatasegenotype–phenotype associationhypophosphatasiapremature tooth loss

Identifiers

PMID36613725
PMCPMC9820760
OpenAlexW4313245869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.