Evidence map›Paper›PMID 36613717›Full record

ArticleInternational journal of molecular sciences2022

HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2).

Fadhel A Alomar, Chengju Tian, Sean R Bidasee, Zachary L Venn, Evan Schroder, Nicholas Y Palermo, Mohammad AlShabeeb, Benson J Edagwa, Jason J Payne, Keshore R Bidasee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Validation of reliable reference genes for qPCR of CD4+ T cells exposed to compressive strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
    Article
  3. Review
  4. The role of autophagy in the progression of HIV infected cardiomyopathy.Frontiers in cell and developmental biology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fadhel A AlomarDepartment of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.ORCID 0000-0003-0788-6919
Chengju TianDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sean R BidaseeDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Zachary L VennDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-5634-959X
Evan SchroderDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-7342-5796
Nicholas Y PalermoVice Chancellor for Research Cores, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Mohammad AlShabeebPopulation Health Research Section, King Abdullah International Medical Research Center, King Saudi bin Abdulaziz University for Health Sciences, Riyadh 11426, Saudi Arabia.ORCID 0000-0002-8885-6254
Benson J EdagwaDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jason J PayneDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Keshore R BidaseeDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-4165-8362
University of Nebraska Medical Center · USImam Abdulrahman Bin Faisal University · SAKing Saud bin Abdulaziz University for Health Sciences · SA

Funding

Diastolic Heart Failure in HIV-1 infectionR01HL164306 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BIDASEE, KESHORE R, GORANTLA, SANTHI · 2022 to 2024
$1.9M
Diastolic dysfunction in HIV infectionR56HL151602 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BIDASEE, KESHORE R, GORANTLA, SANTHI · 2020 to 2020
$586k
NHLBI NIH HHS R01 HL164306NIH HHS R56 HL151602-01A1 and R01HL164306-01
6 · The paper itself

Abstract

The incidence of sudden cardiac death (SCD) in people living with HIV infection (PLWH), especially those with inadequate viral suppression, is high and the reasons for this remain incompletely characterized. The timely opening and closing of type 2 ryanodine receptor (RyR2) is critical for ensuring rhythmic cardiac contraction-relaxation cycles, and the disruption of these processes can elicit Ca

Indexed as

Anti-HIV AgentsHIV InfectionsAlkynesAtazanavir SulfateBenzoxazinesCyclopropanesHumansMolecular Docking SimulationOligopeptidesPyridinesRitonavirRyanodine Receptor Calcium Release ChannelAlkynesAnti-HIV AgentsAtazanavir SulfateBenzoxazinesCyclopropanesefavirenzOligopeptidesPyridinesRitonavirRyanodine Receptor Calcium Release Channel[3H]ryanodineantiretroviral drugsHIVHIV-Tatsingle-channel analysissudden cardiac deathtype 2 ryanodine receptor (RyR2)

Identifiers

PMID36613717
PMCPMC9820108
OpenAlexW4313260521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.