Evidence map›Paper›PMID 36613647›Full record

ArticleInternational journal of molecular sciences2022

Novel Chiral Ru(II) Complexes as Potential c-myc G-quadruplex DNA Stabilizers Inducing DNA Damage to Suppress Triple-Negative Breast Cancer Progression.

Chanling Yuan, Zhixiang Wang, Zongtao Wang, Wentao Liu, Guohu Li, Jinlan Meng, Ruzhen Wu, Qiong Wu, Jiacheng Wang, Wenjie Mei

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 14 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chanling YuanSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhixiang WangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zongtao WangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wentao LiuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guohu LiSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Jinlan MengDepartment of Physiology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Ruzhen WuSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Qiong WuInstitute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 530316, China.
Jiacheng WangSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wenjie MeiSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guangdong Pharmaceutical University · CN

Funding

China Postdoctoral Science Foundation 2017M610576National Natural Science Foundation of China 81572926 and 81703349
6 · The paper itself

Abstract

Currently, effective drugs for triple-negative breast cancer (TNBC) are lacking in clinics. c-myc is one of the core members during TNBC tumorigenesis, and G-rich sequences in the promoter region can form a G-quadruplex conformation, indicating that the c-myc inhibitor is a possible strategy to fight cancer. Herein, a series of chiral ruthenium(II) complexes ([Ru(bpy)

Indexed as

Antineoplastic AgentsCoordination ComplexesG-QuadruplexesRutheniumTriple Negative Breast NeoplasmsAnimalsDNADNA DamageHumansZebrafishAntineoplastic AgentsCoordination ComplexesDNARutheniumchiral ruthenium(II) complexesc-myc G-quadruplex DNAtriple-negative breast cancer

Identifiers

PMID36613647
PMCPMC9820592
OpenAlexW4312172258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.