Role of Nitric Oxide-Derived Metabolites in Reactions of Methylglyoxal with Lysine and Lysine-Rich Protein Leghemoglobin.

Konstantin B Shumaev, Olga V Kosmachevskaya, Elvira I Nasybullina, Enno K Ruuge, Alexey F Topunov

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.8field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Konstantin B ShumaevBach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.

Olga V KosmachevskayaBach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.

Elvira I NasybullinaBach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.

Enno K RuugeE.I. Chazov National Medical Research Center of Cardiology, 121552 Moscow, Russia.

Alexey F TopunovBach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-6625-7373

A N Bach Institute of Biochemistry · RUNational Medical Research Center of Cardiology · RU

Funding

Ministry of Science and Higher Education of the Russian Federation agreement No. 075-15-2022-318 on 20 April 2022

6 · The paper itself

Abstract

Carbonyl stress occurs when reactive carbonyl compounds (RCC), such as reducing sugars, dicarbonyls etc., accumulate in the organism. The interaction of RCC carbonyl groups with amino groups of molecules is called the Maillard reaction. One of the most active RCCs is α-dicarbonyl methylglyoxal (MG) that modifies biomolecules forming non-enzymatic glycation products. Organic free radicals are formed in the reaction between MG and lysine or Nα-acetyllysine. S-nitrosothiols and nitric oxide (

Indexed as

Carcinoma, Renal CellKidney NeoplasmsFree RadicalsGlycation End Products, AdvancedHemoglobinsHumansLeghemoglobinLysineMaillard ReactionNitric OxidePyruvaldehydeFree RadicalsGlycation End Products, AdvancedHemoglobinsLeghemoglobinLysineNitric OxidePyruvaldehydecarbonyl stresselectron paramagnetic resonanceleghemoglobinlysineMaillard reactionmethylglyoxalnitric oxide

Identifiers

PMID36613614

DOI10.3390/ijms24010168

PMCPMC9820652

OpenAlexW4312187925

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.