Evidence map›Paper›PMID 36613578›Full record

ArticleInternational journal of molecular sciences2022

Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification.

Andrey S Drozdov, Kristina S Komarova, Elizaveta N Mochalova, Elena N Komedchikova, Victoria O Shipunova, Maxim P Nikitin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrey S DrozdovMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.ORCID 0000-0001-7260-3095
Kristina S KomarovaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.
Elizaveta N MochalovaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.ORCID 0000-0002-3157-7158
Elena N KomedchikovaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.ORCID 0000-0002-5115-3774
Victoria O ShipunovaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.ORCID 0000-0001-6361-1042
Maxim P NikitinMoscow Institute of Physics and Technology, 141701 Dolgoprudny, Moscow Region, Russia.
Moscow Institute of Physics and Technology · RU

Funding

MSHE of RF 075-00958-21-05 (project 730000F.99.1.BV10AA00006)MSHE of RF 075-03-2022-107 (project 0714-2020-0004)Russian Science Foundation 21-14-00269
6 · The paper itself

Abstract

Nanostructured materials and systems find various applications in biomedical fields. Hybrid organo-inorganic nanomaterials are intensively studied in a wide range of areas, from visualization to drug delivery or tissue engineering. One of the recent trends in material science is biomimetic approaches toward the synthesis or modification of functional nanosystems. Here, we describe an approach toward multifunctional nanomaterials through the biomimetic polymerization of dopamine derivatives. Magnetite nanoparticles were modified with a combination of dopamine conjugates to give multifunctional magneto-fluorescent nanocomposites in one synthetic step. The obtained material showed excellent biocompatibility at concentrations up to 200 μg/mL and an in vivo biodistribution profile typical for nanosized formulations. The synthesized systems were conjugated with antibodies against HER2 to improve their selectivity toward HER2-positive cancer cells. The produced material can be used for dual magneto-optical in vivo studies or targeted drug delivery. The applied synthetic strategy can be used for the creation of various multifunctional hybrid nanomaterials in mild conditions.

Indexed as

Magnetite NanoparticlesNanoparticlesBiomimeticsColoring AgentsDopamineDrug Delivery SystemsTissue DistributionColoring AgentsDopamineMagnetite Nanoparticlesbiodistributiondopaminehybrid materialsin vivo imagingmagnetitesurface modification

Identifiers

PMID36613578
PMCPMC9820170
OpenAlexW4312188126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.