Evidence map›Paper›PMID 36613306›Full record

ArticleFoods (Basel, Switzerland)2022

Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation.

Kirsi Savijoki, Paola San-Martin-Galindo, Katriina Pitkänen, Minnamari Edelmann, Annika Sillanpää, Cim van der Velde, Ilkka Miettinen, Jayendra Z Patel, Jari Yli-Kauhaluoma, Mataleena Parikka and 2 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. In silico prospection of Lactobacillus acidophilus strains with potential probiotic activity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kirsi SavijokiDepartment of Food and Nutrition, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0001-5325-925X
Paola San-Martin-GalindoDrug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Katriina PitkänenDepartment of Food and Nutrition, University of Helsinki, FI-00014 Helsinki, Finland.
Minnamari EdelmannDepartment of Food and Nutrition, University of Helsinki, FI-00014 Helsinki, Finland.
Annika SillanpääDepartment of Food and Nutrition, University of Helsinki, FI-00014 Helsinki, Finland.
Cim van der VeldeDrug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Ilkka MiettinenDrug Research Program, Division of Pharmaceutical Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.
Jayendra Z PatelDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0002-2562-1888
Jari Yli-KauhaluomaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0003-0370-7653
Mataleena ParikkaFaculty of Medicine and Health Technology, University of Tampere, FI-33014 Tampere, Finland.
Adyary FallareroFisher Scientific Ltd., FI-01620 Vantaa, Finland.
Pekka VarmanenDepartment of Food and Nutrition, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0002-4508-3060
University of Helsinki · FITampere University · FIThermo Fisher Scientific (Finland) · FI

Funding

Academy of Finland 322012Academy of Finland 325784Academy of Finland 348973Jane and Aatos Erkko Foundation 2017-19Novo Nordisk Foundation NNF20OC0065096
6 · The paper itself

Abstract

Disrupting bacterial quorum sensing (QS) signaling is a promising strategy to combat pathogenic biofilms without the development of antibiotic resistance. Here, we report that food-associated bacteria can interfere with the biofilm formation of a Gram-negative pathogenic bacterium by targeting its AHL (acyl-homoserine lactone) QS system. This was demonstrated by screening metabolic end-products of different lactobacilli and propionibacteria using Gram-negative and biofilm-forming

Indexed as

acetic acidAHLanti-biofilmChromobacterium violaceumfoodlactobacillipropionibacteriaPropionibacteriumpropionic acidquorum-sensingviolacein

Identifiers

PMID36613306
PMCPMC9818890
OpenAlexW4313247146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.