Evidence map›Paper›PMID 36613093›Full record

ArticleInternational journal of environmental research and public health2022

Minimal Clinically Important Differences (MCID) for the Functional Assessment of Chronic Illness Therapy Fatigue Scale in Patients with Systemic Sclerosis.

Franciska Kiss, Nelli Farkas, Gabriella Nagy, Tünde Minier, Gábor Kumánovics, Réka Faludi, László Czirják, Cecília Varjú

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Observational
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Franciska KissDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.ORCID 0000-0003-0705-635X
Nelli FarkasInstitute of Bioanalysis, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Gabriella NagyDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.
Tünde MinierDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.ORCID 0000-0003-0983-2092
Gábor KumánovicsDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.ORCID 0000-0001-8500-2918
Réka FaludiHeart Institute, Medical School, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-8812-7000
László CzirjákDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.
Cecília VarjúDepartment of Rheumatology and Immunology, Medical School, University of Pécs, H-7632 Pécs, Hungary.ORCID 0000-0002-6849-9114
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Systemic sclerosis (SSc) is characterized by significant fatigue, causing diminished quality of life (QoL). The aim of this study was to examine fatigue levels and their associations with clinical factors and determine the minimal clinically important difference (MCID) value for the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-FS). (2) Methods: A total of 160 SSc patients and 62 individuals without SSc were followed-up over a 12-month period by measuring the FACIT-FS and the Visual Analogue Scale and the Short Form 36 Vitality Score analyzing changes in exhaustion. (3) Results: Fatigue was strongly correlated with HRQoL, level of pain, emotional disorders, physical capability and functionality. The MCID values for FACIT-FS were calculated as -3 for deterioration and +4 for improvement after a 12-month follow-up. The predictors of improvement of fatigue from baseline parameters were the significant disease activity, the patients' poorer functionality and the short disease duration. Patients with scleroderma-related interstitial lung disease at baseline had approximately tripled risks for worsening fatigue. The independent influential factors regarding the changing of FACIT-FS were improving or worsening in the same direction in reference to physical condition, gastrointestinal and emotional factors. (4) Conclusions: Fatigue is a multi-dimensional symptom, which is strongly correlated to HRQoL. MCID values of FACIT-FS can be useful tools in monitoring the changes of HRQoL in clinical trials and in daily practice among patients with SSc.

Indexed as

Lung DiseasesScleroderma, SystemicChronic DiseaseFatigueHumansMinimal Clinically Important DifferenceQuality of LifeSeverity of Illness Indexfatiguefatigue scalefunctional assessment of chronic illness therapyhealth-related quality of lifeminimal clinically important differencesystemic sclerosis

Identifiers

PMID36613093
PMCPMC9819291
OpenAlexW4313471831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.