Evidence map›Paper›PMID 36612225›Full record

ArticleCancers2022

Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.

Lucia Calthorpe, Fernanda Romero-Hernandez, Phoebe Miller, Patricia C Conroy, Kenzo Hirose, Alex Kim, Kimberly Kirkwood, Eric Nakakura, Carlos Corvera, Ajay V Maker and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lucia CalthorpeDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Fernanda Romero-HernandezDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Phoebe MillerDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Patricia C ConroyDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Kenzo HiroseDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Alex KimDepartment of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA.
Kimberly KirkwoodDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Eric NakakuraDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Carlos CorveraDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Ajay V MakerDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Adnan AlseidiDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.
Mohamed Abdelgadir AdamDepartment of Surgery, Division of Surgical Oncology, University of California, San Francisco, CA 94143, USA.

Funding

Surgical Oncology Training GrantT32CA251070 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ESSERMAN, LAURA J · 2020 to 2024
$1.5M
NCI NIH HHS T32 CA251070
6 · The paper itself

Abstract

Background: Malignant peritoneal mesothelioma (MPM) is a rare disease with a historically poor prognosis. Given the emergence of effective therapies, a contemporary analysis of MPM incidence and survival is warranted. Methods: The SEER-18 registry dataset was analyzed (2000−2018). Age-adjusted annual incidence was stratified by sex and histology. Joinpoint regression was used to estimate annual percent change (APC) in incidence. Multivariable cox proportional hazards models were used to investigate survival trends. Results: Of 1689 MPM cases, most were male (55.4%), >50 years (80.0%), and white (75.2%). Age-adjusted incidence of MPM remained stable over time, with an average annual incidence of 1.02 cases/million. Epithelioid histology increased by 240% (APC 2.6; 95% CI: 0.7, 4.5), while incidence of undefined histology decreased significantly (APC −2.1; 95% CI: −3.1, −1.1). Cases treated with cancer-directed surgery increased from 27% to 43%. Overall median age-standardized survival was 11.6 months. Median age-standardized survival was 16.6 months for epithelioid histology but 2.0 months for sarcomatoid histology. Diagnosis in recent years (2015−2018 HR 0.51; 95% CI: 0.38, 0.67) and receipt of cancer-directed surgery (HR 0.84; 95% CI: 0.72, 0.98) were associated with improved survival. Conclusions: Although the overall incidence of MPM remained stable, recognition of epithelioid histology increased. Concurrent with an increase in cancer-directed surgery, MPM survival has improved.

Indexed as

cytoreductive surgeryhyperthermic intraperitoneal chemotherapymesothelioma

Identifiers

PMID36612225
PMCPMC9818958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.