Evidence map›Paper›PMID 36612094›Full record

ArticleCancers2022

Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited.

Karin Byskata, Monika Lukoseviciute, Filippo Tuti, Mark Zupancic, Ourania N Kostopoulou, Stefan Holzhauser, Tina Dalianis

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karin ByskataDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Monika LukoseviciuteDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Filippo TutiDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.ORCID 0000-0001-6967-8387
Mark ZupancicDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.ORCID 0000-0003-4013-7688
Ourania N KostopoulouDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Stefan HolzhauserDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Tina DalianisDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.
Karolinska University Hospital · SE

Funding

Åke Wiberg foundation: M20-0061, M21-0012,Karolinska Institutet 2018-2023Stiftelsen AnnaBrita and Bo Casters Minne LA2019-0080, LA2020-0012, LA2021-0019Stiftelsen Sigurd och Elsa Goljes Minne LA2019-0143; LA2020-0077; LA2020-0070; LA2021-0028; LA2022-0110Svenska Läkarsällskapet SLS-934161The Royal Swedish Academy of Sciences 2017-2018The Stockholm Cancer Foundation 20 0704)The Stockholm Cancer Society 201092The Swedish Cancer and Allergy Foundation 10367The Swedish Child Cancer Foundation TJ2022-0067
6 · The paper itself

Abstract

Human papillomavirus positive (HPV

Indexed as

APR-246base of tongue cancerhead and neck cancerHPVoropharyngeal cancerPARP inhibitorsPI3K inhibitorstargeted therapytonsillar cancerWEE1 inhibitors

Identifiers

PMID36612094
PMCPMC9818008
OpenAlexW4313247320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.