Evidence map›Paper›PMID 36612089›Full record

ArticleCancers2022

Free and Poly-Methyl-Methacrylate-Bounded BODIPYs: Photodynamic and Antimigratory Effects in 2D and 3D Cancer Models.

Marco Ballestri, Emanuela Marras, Enrico Caruso, Fabrizio Bolognese, Miryam Chiara Malacarne, Elisa Martella, Matilde Tubertini, Marzia Bruna Gariboldi, Greta Varchi

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marco BallestriInstitute for the Organic Synthesis and Photoreactivity, Italian National Research Council, 40129 Bologna, Italy.ORCID 0000-0001-7336-2131
Emanuela MarrasDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, 21100 Varese, Italy.
Enrico CarusoDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-6700-911X
Fabrizio BologneseDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, 21100 Varese, Italy.
Miryam Chiara MalacarneDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-3779-7231
Elisa MartellaInstitute for the Organic Synthesis and Photoreactivity, Italian National Research Council, 40129 Bologna, Italy.ORCID 0000-0003-3923-0906
Matilde TubertiniInstitute for the Organic Synthesis and Photoreactivity, Italian National Research Council, 40129 Bologna, Italy.
Marzia Bruna GariboldiDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-5683-0885
Greta VarchiInstitute for the Organic Synthesis and Photoreactivity, Italian National Research Council, 40129 Bologna, Italy.ORCID 0000-0002-8358-3437
University of Insubria · ITInstitute of Organic Synthesis and Photoreactivity · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several limitations, including dark toxicity, reduced tumor tissue selectivity, low photostability and poor biocompatibility hamper the clinical use of Photodynamic therapy (PDT) in cancer treatment. To overcome these limitations, new PSs have been synthetized, and often combined with drug delivery systems, to improve selectivity and reduce toxicity. In this context, BODIPYs (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) have recently emerged as promising and easy-to-handle scaffolds for the preparation of effective PDT antitumor agents. In this study, the anticancer photodynamic effect of newly prepared negatively charged polymethyl methacrylate (nPMMA)-bounded BODIPYs (

Indexed as

antitumor efficacyBODIPYsdrug deliveryelectrostatic loadinginhibition of cells migrationphotodynamic therapypoly-methyl methacrylate nanoparticles

Identifiers

PMID36612089
PMCPMC9817850
OpenAlexW4313260902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.