Evidence map›Paper›PMID 36612071›Full record

ArticleCancers2022

EBV and MSI Status in Gastric Cancer: Does It Matter?

Catarina Neto do Nascimento, Luís Mascarenhas-Lemos, João Ricardo Silva, Diogo Sousa Marques, Catarina Ferreira Gouveia, Ana Faria, Sónia Velho, Rita Garrido, Rui Maio, Andreia Costa and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Perioperative immunotherapy in gastric cancer in the spotlight.World journal of clinical oncology · 2025
    Review
  4. Article
  5. Review
  6. Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Catarina Neto do NascimentoDepartment of Gastroenterology, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.ORCID 0000-0002-8864-1739
Luís Mascarenhas-LemosFaculty of Medicine, Catholic University of Portugal, 2635-631 Rio de Mouro, Portugal.
João Ricardo SilvaFaculty of Medicine, University of Porto (FMUP), 4200-319 Porto, Portugal.ORCID 0000-0001-8579-6543
Diogo Sousa MarquesFaculty of Medicine, University of Porto (FMUP), 4200-319 Porto, Portugal.ORCID 0000-0002-4862-3982
Catarina Ferreira GouveiaDepartment of Gastroenterology, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
Ana FariaDepartment of Oncology, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
Sónia VelhoDepartment of Dietetics and Nutrition, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.ORCID 0000-0002-0879-9430
Rita GarridoDepartment of General Surgery, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
Rui MaioDepartment of General Surgery, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal.
Andreia CostaDepartment of Oncology, Centro Hospitalar Universitário de São João (CHUSJ), 4200-319 Porto, Portugal.
Patrícia PontesDepartment of Pathology, Centro Hospitalar Universitário de São João (CHUSJ), 4200-319 Porto, Portugal.
Xiaogang Weni3S-Instituto de Investigação e Inovação em Saúde and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup), 4200-135 Porto, Portugal.
Irene GulloFaculty of Medicine, University of Porto (FMUP), 4200-319 Porto, Portugal.
Marília CravoDepartment of Gastroenterology, Hospital da Luz de Lisboa, 1500-650 Lisboa, Portugal.
Fátima CarneiroFaculty of Medicine, University of Porto (FMUP), 4200-319 Porto, Portugal.ORCID 0000-0002-1964-1006
Hospital Beatriz Ângelo · PTUniversidade do Porto · PTHospital de São João · PTHospital da Luz · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTUniversidade Católica Portuguesa · PTUniversity of Lisbon · PT

Funding

Hospital da Luz LH.INV.F2019015
6 · The paper itself

Abstract

We investigated the impactof microsatellite instability (MSI) and Epstein-Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridization. Thirty-seven (27%) cases presented as MSI-high, and seven (5.1%) were EBV+. Concerning tumor regression after POPChT, no differences were observed between the molecular subtypes, but females were more likely to respond (

Indexed as

Epstein–Barr virusfemalesgastric cancergendermicrosatellite instabilitymolecular subtypeneoadjuvant chemotherapyperioperative chemotherapy predictorprognosis

Identifiers

PMID36612071
PMCPMC9817503
OpenAlexW4312173687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.