Evidence map›Paper›PMID 36612049›Full record

ArticleCancers2022

Voltage-Gated Sodium Channel Na

Osbaldo Lopez-Charcas, Lucile Poisson, Oumnia Benouna, Roxane Lemoine, Stéphanie Chadet, Adrien Pétereau, Widad Lahlou, Serge Guyétant, Mehdi Ouaissi, Piyasuda Pukkanasut and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Cancer: A bioelectric disease?Clinical and translational medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. A novel NaOncogene · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Osbaldo Lopez-CharcasEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.ORCID 0000-0002-5080-8310
Lucile PoissonEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.
Oumnia BenounaEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.ORCID 0000-0003-1530-6953
Roxane LemoineEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.ORCID 0000-0002-9889-3614
Stéphanie ChadetEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.
Adrien PétereauService D'anatomie et de Cytologie Pathologiques, Hôpital Trousseau, CHU de Tours, 37170 Tours, France.
Widad LahlouService D'hépato-Gastroentérologie et de Cancérologie Digestive, Hôpital Trousseau, CHU de Tours, 37170 Tours, France.
Serge GuyétantService D'anatomie et de Cytologie Pathologiques, Hôpital Trousseau, CHU de Tours, 37170 Tours, France.ORCID 0000-0003-2783-9722
Mehdi OuaissiEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.
Piyasuda PukkanasutDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294-1240, USA.ORCID 0000-0002-0726-3060
Shilpa DuttaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294-1240, USA.
Sadanandan E VeluDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294-1240, USA.ORCID 0000-0002-0342-2378
Pierre BessonEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.ORCID 0000-0003-1257-8005
Driffa MoussataEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.
Sébastien RogerEA4245, Transplantation, Immunologie et Inflammation, Faculté de Médecine, Université de Tours, 37032 Tours, France.ORCID 0000-0002-9852-5248
Université de Tours · FRCentre Hospitalier Universitaire de Tours · FRUniversity of Alabama at Birmingham · US

Funding

Somatostatin receptor 2 (SSTR2) antibody-drug conjugate for pancreatic neuroendocrine tumor (PanNET) therapyR21CA226491 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JASKULA-SZTUL, RENATA, LIU, XIAOGUANG MARGARET · 2020 to 2021
$364k
Fondation pour la Recherche Médicale SPF201909009198Inserm-Region Centre-Val de Loire PhD fellowshipMinistère de la Recherche et des Technologies, the Ligue Nationale Contre le Cancer, Interrégion Grand-Ouest: comités 29, 36, 86, 37, the Région Centre-Val de Loire Grant No. NavMetargetNIH HHS 1R21CA226491O'Neal Comprehensive Cancer Center Pre-R01 grantPrize Prix Ruban Rose Avenir 2017 from the charity "Le Cancer du sein: parlons-en!" Prix Ruban Rose Avenir 2017Région Centre-Val de Loire grant "CanalEx"
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the second leading cause of death worldwide, with 0.9 million deaths per year. The metastatic stage of the disease is identified in about 20% of cases at the first diagnosis and is associated with low patient-survival rates. Voltage-gated sodium channels (Na

Indexed as

cell invasivenesscolon cancerNaV channelsproton effluxsmall-molecule inhibitors

Identifiers

PMID36612049
PMCPMC9817685
OpenAlexW4312073583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.