Evidence map›Paper›PMID 36612041›Full record

ArticleCancers2022

Locally Performed HRD Testing for Ovarian Cancer? Yes, We Can!

Gilda Magliacane, Emanuela Brunetto, Silvia Calzavara, Alice Bergamini, Giovanni Battista Pipitone, Giovanna Marra, Miriam Redegalli, Greta Grassini, Emanuela Rabaiotti, Gianluca Taccagni and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. HRD Testing of Ovarian Cancer in Routine Practice: What Are We Dealing With?International journal of molecular sciences · 2023
    Article
  14. Review
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Gilda MagliacanePathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Emanuela BrunettoPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Silvia CalzavaraLaboratory of Clinical Molecular Biology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Alice BergaminiObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Giovanni Battista PipitoneLaboratory of Clinical Molecular Biology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-2265-3646
Giovanna MarraPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Miriam RedegalliPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-5308-280X
Greta GrassiniPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Emanuela RabaiottiObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Gianluca TaccagniPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Lorenza PecciariniPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Paola CarreraLaboratory of Clinical Molecular Biology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Giorgia MangiliObstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Claudio DoglioniPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-4969-5216
Maria Giulia CangiPathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-9472-0935
Vita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of HRD status is now essential for ovarian cancer patient management. A relevant percentage of high-grade serous carcinoma (HGSC) is characterized by HRD, which is caused by genetic alterations in the homologous recombination repair (HRR) pathway. Recent trials have shown that not only patients with pathogenic/likely pathogenic

Indexed as

BRCAHRDHRRmolecular testingNGSovarian cancerPARPi

Identifiers

PMID36612041
PMCPMC9817883
OpenAlexW4313574130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.