ArticleCancers2022
Dynamic Optical Coherence Tomography: A Non-Invasive Imaging Tool for the Distinction of Nevi and Melanomas.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Longitudinal investigation of prostate tumor spheroid proliferation with dynamic line-field optical coherence tomography.Biomedical optics express · 2026Article
- [In vivo reflectance confocal microscopy and melanocytic tumors].Dermatologie (Heidelberg, Germany) · 2025Article
- Impact of image preprocessing on dermatological OCTA vessel segmentation: a DERMA-OCTA study.Journal of biomedical optics · 2025Article
- Use of non-invasive optical imaging techniques in dermatology.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Review
- DERMA-OCTA: A Comprehensive Dataset and Preprocessing Pipeline for Dermatological OCTA Vessel Segmentation.Scientific data · 2025Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Monte Carlo-based realistic simulation of optical coherence tomography angiography.Biomedical optics express · 2025Article
- Optical coherence tomography angiography enables visualization of microvascular patterns in chronic venous insufficiency.iScience · 2024Article
- Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation.Biomedical optics express · 2024Article
- Dynamic optical coherence tomography unveils subclinical, vascular differences across actinic keratosis grades I-III.Experimental dermatology · 2024Article
- Non-Invasive Diagnostic Techniques in Dermatology.Journal of clinical medicine · 2023Article
- Advancements in Dermatological Imaging Modalities.Indian dermatology online journalArticle
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Along with the rising melanoma incidence in recent decades and bad prognoses resulting from late diagnoses, distinguishing between benign and malignant melanocytic lesions has become essential. Unclear cases may require the aid of non-invasive imaging to reduce unnecessary biopsies. This multicentric, case-control study evaluated the potential of dynamic optical coherence tomography (D-OCT) to identify distinguishing microvascular features in nevi. A total of 167 nevi, including dysplastic ones, on 130 participants of all ages and sexes were examined by D-OCT and dermoscopy with a histological reference. Three blinded analyzers evaluated the lesions. Then, we compared the features to those in 159 melanomas of a prior D-OCT study and determined if a differential diagnosis was possible. We identified specific microvascular features in nevi and a differential diagnosis of melanomas and nevi was achieved with excellent predictive values. We conclude that D-OCT overcomes OCT´s inability to distinguish melanocytic lesions based on its focus on microvascularization. To determine if an addition to the gold standard of a clinical-dermoscopic examination improves the diagnosis of unclear lesions, further studies, including a larger sample of dysplastic nevi and artificial intelligence, should be conducted.
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