Evidence map›Paper›PMID 36611985›Full record

ArticleCells2023

Pervasive Platelet Secretion Defects in Patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

Johannes Kalbhenn, Jan-Steffen Pooth, Georg Trummer, David Kranzhöfer, Axel Schlagenhauf, Barbara Zieger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Johannes KalbhennDepartment of Anesthesiology and Critical Care, Medical Center, Faculty of Medicine, University of Freiburg, 79110 Freiburg im Breisgau, Germany.
Jan-Steffen PoothDepartment of Emergency Medicine, Faculty of Medicine, Medical Center-University of Freiburg, 79098 Freiburg im Breisgau, Germany.ORCID 0000-0001-6882-2009
Georg TrummerDepartment of Cardiovascular Surgery, Faculty of Medicine, Medical Center-University of Freiburg, 79098 Freiburg im Breisgau, Germany.
David KranzhöferDepartment for General Pediatrics, Adolescent Medicine and Neonatology, University Medical Center of Freiburg, 79098 Freiburg im Breisgau, Germany.
Axel SchlagenhaufDivision of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria.
Barbara ZiegerDivision of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center-University of Freiburg, 79098 Freiburg im Breisgau, Germany.
University of Freiburg · DEMedical University of Graz · ATUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critically ill COVID-19 patients suffer from thromboembolic as well as bleeding events. Endothelial dysfunction, spiking of von Willebrand factor (vWF), and excessive cytokine signaling result in coagulopathy associated with substantial activation of plasmatic clotting factors. Thrombocytopenia secondary to extensive platelet activation is a frequent finding, but abnormal platelet dysfunction may also exist in patients with normal platelet counts. In this study, we performed analyses of platelet function and of von Willebrand factor in critically ill COVID-19 patients (

Indexed as

COVID-19ThrombocytopeniaCollagenCritical IllnessHemostasisHumansPlatelet AggregationSARS-CoV-2von Willebrand FactorCollagenvon Willebrand FactorCOVID-19platelet secretionvon Willebrand factor

Identifiers

PMID36611985
PMCPMC9818980
OpenAlexW4313583181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.