Evidence map›Paper›PMID 36611973›Full record

ArticleCells2023

Identification and Validation of the Prognostic Panel in Clear Cell Renal Cell Carcinoma Based on Resting Mast Cells for Prediction of Distant Metastasis and Immunotherapy Response.

Yang Su, Tianxiang Zhang, Jinsen Lu, Lei Qian, Yang Fei, Li Zhang, Song Fan, Jun Zhou, Jieqiong Tang, Haige Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  14. LowTranslational cancer research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yang SuDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Tianxiang ZhangDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.ORCID 0000-0001-5058-3003
Jinsen LuNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK.ORCID 0000-0002-5239-5361
Lei QianDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.
Yang FeiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.
Li ZhangDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Song FanDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Jun ZhouDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Jieqiong TangDepartment of Cardiology, Chuzhou Hospital Affiliated to Anhui Medical University, Chuzhou 239000, China.
Haige ChenDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.
Chaozhao LiangDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Anhui Medical University · CNShanghai Jiao Tong University · CNNuffield Orthopaedic Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) has a high metastatic rate, and its incidence and mortality are still rising. The aim of this study was to identify the key tumor-infiltrating immune cells (TIICs) affecting the distant metastasis and prognosis of patients with ccRCC and to construct a relevant prognostic panel to predict immunotherapy response. Based on ccRCC bulk RNA sequencing data, resting mast cells (RMCs) were screened and verified using the CIBERSORT algorithm, survival analysis, and expression analysis. Distant metastasis-associated genes were identified using single-cell RNA sequencing data. Subsequently, a three-gene (

Indexed as

CarcinomaCarcinoma, Renal CellKidney NeoplasmsAdaptor Proteins, Signal TransducingHumansImmunotherapyMast CellsPrognosisAdaptor Proteins, Signal TransducingTOM1L1 protein, humanclear cell renal cell carcinomadistant metastasisimmunotherapyprognostic panelresting mast cellstumor microenvironment

Identifiers

PMID36611973
PMCPMC9818872
OpenAlexW4313472298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.