Evidence map›Paper›PMID 36611969›Full record

ArticleCells2022

Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction.

Bernd Frerker, Stefan Fiedler, Timo Kirschstein, Falko Lange, Katrin Porath, Tina Sellmann, Leonie Kutzner, Fabian Wilde, Julian Moosmann, Rüdiger Köhling and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Bernd FrerkerDepartment of Radiation Oncology, Rostock University Medical Center, 18059 Rostock, Germany.
Stefan FiedlerEuropean Molecular Biology Laboratory, 22607 Hamburg, Germany.ORCID 0000-0002-3623-3311
Timo KirschsteinOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.
Falko LangeOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0001-8782-5205
Katrin PorathOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.
Tina SellmannOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.
Leonie KutznerOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.
Fabian WildeHelmholtz-Zentrum Hereon, X-ray Imaging with Synchrotron Radiation, Hereon Outstation, 21502 Geesthacht, Germany.
Julian MoosmannHelmholtz-Zentrum Hereon, X-ray Imaging with Synchrotron Radiation, Hereon Outstation, 21502 Geesthacht, Germany.
Rüdiger KöhlingOscar Langendorff Institute of Physiology, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0003-3330-4898
Guido HildebrandtDepartment of Radiation Oncology, Rostock University Medical Center, 18059 Rostock, Germany.
Elisabeth SchültkeDepartment of Radiation Oncology, Rostock University Medical Center, 18059 Rostock, Germany.
University of Rostock · DEHelmholtz-Zentrum Hereon · DEEuropean Molecular Biology Laboratory · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-dose-rate radiotherapy has shown promising results with respect to normal tissue preservation. We developed an ex vivo model to study the physiological effects of experimental radiotherapy in the rodent esophageal smooth muscle.

methodsWe assessed the physiological parameters of the esophageal function in ex vivo preparations of the proximal, middle, and distal segments in the organ bath. High-dose-rate synchrotron irradiation was conducted using both the microbeam irradiation (MBI) technique with peak doses greater than 200 Gy and broadbeam irradiation (BBI) with doses ranging between 3.5-4 Gy.

resultsNeither MBI nor BBI affected the function of the contractile apparatus. While peak latency and maximal force change were not affected in the BBI group, and no changes were seen in the proximal esophagus segments after MBI, a significant increase in peak latency and a decrease in maximal force change was observed in the middle and distal esophageal segments.

conclusionNo severe changes in physiological parameters of esophageal contraction were determined after high-dose-rate radiotherapy in our model, but our results indicate a delayed esophageal function. From the clinical perspective, the observed increase in peak latency and decreased maximal force change may indicate delayed esophageal transit.

Indexed as

EsophagusRodentiaAnimalsMuscle ContractionMuscle, Smoothbroadbeam irradiationcarbachol-induced contractionesophageal function and motilityesophageal smooth musclehigh-dose-rate radiotherapymicrobeam irradiationorgan bath

Identifiers

PMID36611969
PMCPMC9818134
OpenAlexW4313472844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.