Evidence map›Paper›PMID 36611868›Full record

ArticleCells2022

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL.

Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The PNPLA family of enzymes: characterisation and biological role.Arhiv za higijenu rada i toksikologiju · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hagen Roland WitzelInstitute of Pathology, University Medical Center Mainz, 55131 Mainz, Germany.
Inga Maria Gertrud SchwittaiInstitute of Pathology, University Medical Center Mainz, 55131 Mainz, Germany.
Nils HartmannInstitute of Pathology, University Medical Center Mainz, 55131 Mainz, Germany.
Sebastian MuellerDepartment of Internal Medicine, Salem Medical Center, 69121 Heidelberg, Germany.ORCID 0000-0001-5655-6778
Jörn M SchattenbergMetabolic Liver Research Program, I. Department of Medicine, University Medical Center, 55131 Mainz, Germany.
Xue-Min GongInstitute of Experimental Cardiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Johannes BacksInstitute of Experimental Cardiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Peter SchirmacherInstitute of Pathology, University Medical Center Heidelberg, 69120 Heidelberg, Germany.
Detlef SchuppanTranslational Immunology, Research Center for Immune Therapy, University Medicine Mainz, 55131 Mainz, Germany.
Wilfried RothInstitute of Pathology, University Medical Center Mainz, 55131 Mainz, Germany.
Beate Katharina StraubInstitute of Pathology, University Medical Center Mainz, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DEHeidelberg University · DEBeth Israel Deaconess Medical Center · USKrankenhaus Salem · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The single nucleotide polymorphism I148M of the lipase

Indexed as

Liver NeoplasmsNon-alcoholic Fatty Liver DiseaseAcyltransferasesHumansLipaseLipolysisPerilipin-1Perilipin-5AcyltransferasesLipasePerilipin-1Perilipin-5PNPLA2 protein, humanalcoholic steatohepatitis (ASH)ballooned hepatocyteslipid dropletslipoloysisNAFLDnon-alcoholic steatohepatitis (NASH)perilipinPNPLA3

Identifiers

PMID36611868
PMCPMC9818421
OpenAlexW4312205763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.