Evidence map›Paper›PMID 36611841›Full record

ArticleCells2022

Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys.

Linda Xiaoyan Li, Xu Zhang, Hongbing Zhang, Ewud Agborbesong, Julie Xia Zhou, James P Calvet, Xiaogang Li

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Combination siRNA delivery as a therapeutic strategy for ADPKD.bioRxiv : the preprint server for biology · 2026
    Article
  7. Collecting Duct-Targeted Lipid Nanoparticles DeliverbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Characteristics of PD-1Clinical & translational immunology · 2024
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Linda Xiaoyan LiDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Xu ZhangRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-9784-0481
Hongbing ZhangDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Ewud AgborbesongDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Julie Xia ZhouDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
James P CalvetDepartment of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0001-5928-9820
Xiaogang LiDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clinic · USUniversity of Kansas Medical Center · US

Funding

Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
The crosstalk of DNA and lysine methyltransferases in ADPKD.R01DK126662 · NIDDK · MAYO CLINIC ROCHESTER · PI Xiaogang Li · 2020 to 2026
$3.0M
ADPKD: Understanding immunosuppression mechanisms and discovering treatmentR01DK129241 · NIDDK · MAYO CLINIC ROCHESTER · PI LI, XIAOGANG · 2021 to 2024
$1.8M
NIDDK NIH HHS P30 DK106912NIDDK NIH HHS R01 DK126662NIDDK NIH HHS R01 DK129241NIH HHS DK106912NIH HHS DK126662
6 · The paper itself

Abstract

ADPKD is a genetic disorder with a molecular complexity that remains poorly understood. In this study, we sampled renal cells to construct a comprehensive and spatiotemporally resolved gene expression atlas in whole

Indexed as

Polycystic Kidney, Autosomal DominantPolycystic Kidney DiseasesAnimalsEpithelial CellsKidneyMiceADPKDCellChatPkd1 mutationsingle cell sequencing

Identifiers

PMID36611841
PMCPMC9818381
OpenAlexW4312100125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.