Evidence map›Paper›PMID 36611805›Full record

ArticleCells2022

Significance of Catecholamine Biosynthetic/Metabolic Pathway in SARS-CoV-2 Infection and COVID-19 Severity.

George Mpekoulis, Katerina I Kalliampakou, Raphaela S Milona, Despoina Lagou, Anastasios Ioannidis, Edison Jahaj, Christos T Chasapis, Dionysis Kefallinos, Ioannis Karakasiliotis, Anastasia Kotanidou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

George MpekoulisLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Katerina I KalliampakouLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Raphaela S MilonaLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Despoina LagouLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Anastasios IoannidisDepartment of Nursing, University of Peloponnese, 23100 Sparti, Greece.ORCID 0000-0003-1880-7366
Edison JahajGP Livanos and M Simou Laboratories, First Department of Critical Care Medicine & Pulmonary Services, National and Kapodistrian University of Athens Medical School, Evangelismos Hospital, 10676 Athens, Greece.ORCID 0000-0002-7306-713X
Christos T ChasapisInstitute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece.
Dionysis KefallinosSchool of Electrical Engineering and Computer Science, National Technical University of Athens, 9 Iroon Polytechniou Street, Zografou, 15773 Athens, Greece.
Ioannis KarakasiliotisLaboratory of Biology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-3004-8104
Anastasia KotanidouGP Livanos and M Simou Laboratories, First Department of Critical Care Medicine & Pulmonary Services, National and Kapodistrian University of Athens Medical School, Evangelismos Hospital, 10676 Athens, Greece.ORCID 0000-0002-2508-500X
Stylianos ChatzipanagiotouDepartment of Medical Biopathology, Medical School, University of Athens, Eginition Hospital, 11528 Athens, Greece.ORCID 0000-0002-1251-8355
Dido VassilacopoulouSection of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Alice G VassiliouGP Livanos and M Simou Laboratories, First Department of Critical Care Medicine & Pulmonary Services, National and Kapodistrian University of Athens Medical School, Evangelismos Hospital, 10676 Athens, Greece.ORCID 0000-0003-4984-0476
Emmanouil AngelakisDepartment of Diagnostics, Hellenic Pasteur Institute, Athens 11521, Greece.
Niki VassilakiLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0001-7992-3438
National and Kapodistrian University of Athens · GRPasteur Hellenic Institute · GRAix-Marseille Université · FRDemocritus University of Thrace · GRNational Hellenic Research Foundation · GRNational Technical University of Athens · GRUniversity of Peloponnese · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 infection was previously associated with the expression of the dopamine biosynthetic enzyme L-Dopa decarboxylase (DDC). Specifically, a negative correlation was detected between DDC mRNA and SARS-CoV-2 RNA levels in in vitro infected epithelial cells and the nasopharyngeal tissue of COVID-19 patients with mild/no symptoms. However,

Indexed as

COVID-19Biosynthetic PathwaysCatecholaminesDopamineHumansLevodopaRNA, MessengerRNA, ViralSARS-CoV-2CatecholaminesDopamineLevodopaRNA, MessengerRNA, Viralcatecholamine pathwaydisease severitydopamineL-Dopa decarboxylaseSARS-CoV-2

Identifiers

PMID36611805
PMCPMC9818320
OpenAlexW4313465966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.