ReviewAnimals : an open access journal from MDPI2022
Aggression in Group-Housed Male Mice: A Systematic Review.
Review in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the development and application of home cage monitoring in laboratory mice and rats.BMC biology · 2023Pooled it
- Laboratory conditions matter: social housing in male and female laboratory mice in a multicenter study approach.Lab animal · 2026Article
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Article
- Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway.Oncology reports · 2026Article
- Article
- Ethological Constraints and Welfare-Related Bias in Laboratory Mice: Implications of Housing, Lighting, and Social Environment.Animals : an open access journal from MDPI · 2026Review
- Influence of environmental enrichment on rodents' brains: neurochemical and neuroanatomical aspects.Frontiers in veterinary science · 2026Review
- MCPB-21 targets glycogenin-2 to regulate fatty acid oxidation and promote ferroptosis of breast cancer.American journal of cancer research · 2026Article
- Social Housing of Postoperative Animals to Support Animal Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Environmental Exposure to the Common Trunk of Mammalian Appeasing Pheromone Modulates Social Behavior and Reduces Fight Wounds in Male Mice.Animals : an open access journal from MDPI · 2025Article
- Social Housing of Male CD-1 Mice (Mus musculus) in the Toxicological Setting: A 28-Day Social Compatibility Study of Male Mice following Oral Gavage of Theophylline.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A customised combination of environmental enrichment reduces aggression in CD-1 male mice.Laboratory animals · 2025Article
- Approved Ambiguities: An Analysis of Applications for the Ethical Review of Animal Research in Sweden-Focusing on Harm, Benefit, and the 3Rs.Animals : an open access journal from MDPI · 2025Article
- Article
- Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistantAntimicrobial agents and chemotherapy · 2025Article
- An integrative assay for measuring social aversion and motivation in freely behaving mice.Cell reports methods · 2025Article
- A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice.Hormones and behavior · 2025Article
- Tryptophan hydroxylase 2 deficiency alters autism-related behavioural phenotypes in rats.Scientific reports · 2025Article
- The impact of co-housing on murine aging studies.GeroScience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggression among group-housed male mice is a major animal welfare concern often observed at animal facilities. Studies designed to understand the causes of male mice aggression have used different methodological approaches and have been heterogeneous, using different strains, environmental enrichments, housing conditions, group formations and durations. By conducting a systematic literature review based on 198 observed conclusions from 90 articles, we showed that the methodological approach used to study aggression was relevant for the outcome and suggested that home cage observations were better when studying home cage aggression than tests provoking aggression outside the home cage. The study further revealed that aggression is a complex problem; one solution will not be appropriate for all animal facilities and all research projects. Recommendations were provided on promising tools to minimize aggression, based on the results, which included what type of environmental enrichments could be appropriate and which strains of male mice were less likely to be aggressive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.