Evidence map›Paper›PMID 36611392›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Comprehensive Review on the Use of Artificial Intelligence in Ophthalmology and Future Research Directions.

Nicoleta Anton, Bogdan Doroftei, Silvia Curteanu, Lisa Catãlin, Ovidiu-Dumitru Ilie, Filip Târcoveanu, Camelia Margareta Bogdănici

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Standards for vision science librarians: 2026 review and revisions.Journal of the Medical Library Association : JMLA · 2026
    Review
  5. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  6. Article
  7. Article
  8. Hybrid attention-based deep learning for multi-label ophthalmic disease detection on fundus images.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nicoleta AntonFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No 16, 700115 Iasi, Romania.ORCID 0000-0002-4987-5049
Bogdan DorofteiFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No 16, 700115 Iasi, Romania.ORCID 0000-0002-6618-141X
Silvia CurteanuDepartment of Chemical Engineering, Cristofor Simionescu Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University, Prof.dr.doc Dimitrie Mangeron Avenue, No 67, 700050 Iasi, Romania.
Lisa CatãlinDepartment of Chemical Engineering, Cristofor Simionescu Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University, Prof.dr.doc Dimitrie Mangeron Avenue, No 67, 700050 Iasi, Romania.ORCID 0000-0003-2043-9726
Ovidiu-Dumitru IlieDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University, Carol I Avenue, No 20A, 700505 Iasi, Romania.ORCID 0000-0002-4023-1765
Filip TârcoveanuFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No 16, 700115 Iasi, Romania.
Camelia Margareta BogdăniciFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No 16, 700115 Iasi, Romania.ORCID 0000-0002-9542-7714
Grigore T. Popa University of Medicine and Pharmacy · ROGheorghe Asachi Technical University of Iași · ROAlexandru Ioan Cuza University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHaving several applications in medicine, and in ophthalmology in particular, artificial intelligence (AI) tools have been used to detect visual function deficits, thus playing a key role in diagnosing eye diseases and in predicting the evolution of these common and disabling diseases. AI tools, i.e., artificial neural networks (ANNs), are progressively involved in detecting and customized control of ophthalmic diseases. The studies that refer to the efficiency of AI in medicine and especially in ophthalmology were analyzed in this review. MATERIALS AND

methodsWe conducted a comprehensive review in order to collect all accounts published between 2015 and 2022 that refer to these applications of AI in medicine and especially in ophthalmology. Neural networks have a major role in establishing the demand to initiate preliminary anti-glaucoma therapy to stop the advance of the disease.

resultsDifferent surveys in the literature review show the remarkable benefit of these AI tools in ophthalmology in evaluating the visual field, optic nerve, and retinal nerve fiber layer, thus ensuring a higher precision in detecting advances in glaucoma and retinal shifts in diabetes. We thus identified 1762 applications of artificial intelligence in ophthalmology: review articles and research articles (301 pub med, 144 scopus, 445 web of science, 872 science direct). Of these, we analyzed 70 articles and review papers (diabetic retinopathy (N = 24), glaucoma (N = 24), DMLV (N = 15), other pathologies (N = 7)) after applying the inclusion and exclusion criteria.

conclusionIn medicine, AI tools are used in surgery, radiology, gynecology, oncology, etc., in making a diagnosis, predicting the evolution of a disease, and assessing the prognosis in patients with oncological pathologies. In ophthalmology, AI potentially increases the patient's access to screening/clinical diagnosis and decreases healthcare costs, mainly when there is a high risk of disease or communities face financial shortages. AI/DL (deep learning) algorithms using both OCT and FO images will change image analysis techniques and methodologies. Optimizing these (combined) technologies will accelerate progress in this area.

Indexed as

applications of artificial intelligence in ophthalmologyartificial intelligenceartificial intelligence in medicineglaucoma and artificial intelligenceneural networks in ophthalmology

Identifiers

PMID36611392
PMCPMC9818832
OpenAlexW4313362720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.