ArticleCerebral cortex (New York, N.Y. : 1991)2023
White-matter degradation and dynamical compensation support age-related functional alterations in human brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain.eNeuro · 2026Pooled it
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- The role of connectivity for the degeneracy of the brain's resting state dynamics.Journal of computational neuroscience · 2026Article
- Integrating computational modeling, neuroimaging, and neuromodulation to decompose perceptual decision-making in healthy aging: a review of methods, findings, and gaps.Frontiers in aging neuroscience · 2026Review
- Biophysically constrained dynamical modelling of the brain using multimodal magnetic resonance imaging.Brain research bulletin · 2025Article
- Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.Communications biology · 2025Article
- DySCo: A general framework for dynamic functional connectivity.PLoS computational biology · 2025Article
- Theta and alpha connectivity in children with autism spectrum disorder.Brain communications · 2025Article
- Translational network neuroscience: Nine roadblocks and possible solutions.Network neuroscience (Cambridge, Mass.) · 2025Article
- Article
- 40 Hz light stimulation restores early brain dynamics alterations and associative memory in Alzheimer's disease model mice.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Symmetry breaking organizes the brain's resting state manifold.Scientific reports · 2024Article
- Article
- Virtual brain twins: from basic neuroscience to clinical use.National science review · 2024Review
- EiDA: A lossless approach for dynamic functional connectivity; application to fMRI data of a model of ageing.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure.PLoS computational biology · 2023Article
- State-switching and high-order spatiotemporal organization of dynamic functional connectivity are disrupted by Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2023Article
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3 authors.
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Abstract
Structural connectivity of the brain at different ages is analyzed using diffusion-weighted magnetic resonance imaging (MRI) data. The largest decrease of streamlines is found in frontal regions and for long inter-hemispheric links. The average length of the tracts also decreases, but the clustering is unaffected. From functional MRI we identify age-related changes of dynamic functional connectivity (dFC) and spatial covariation features of functional connectivity (FC) links captured by metaconnectivity. They indicate more stable dFC, but wider range and variance of MC, whereas static features of FC did not show any significant differences with age. We implement individual connectivity in whole-brain models and test several hypotheses for the mechanisms of operation among underlying neural system. We demonstrate that age-related functional fingerprints are only supported if the model accounts for: (i) compensation of the individual brains for the overall loss of structural connectivity and (ii) decrease of propagation velocity due to the loss of myelination. We also show that with these 2 conditions, it is sufficient to decompose the time-delays as bimodal distribution that only distinguishes between intra- and inter-hemispheric delays, and that the same working point also captures the static FC the best, and produces the largest variability at slow time-scales.
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