Evidence map›Paper›PMID 36611078›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2023

Risk factors of early complications after thoracic and lumbar spinal deformity surgery: a systematic review and meta-analysis.

Cathleen C Kuo, Mohamed A R Soliman, Alexander O Aguirre, Dennis Youngs, Marissa Kruk, Ryan M Hess, Elizabeth M Nyabuto, Asham Khan, Patrick K Jowdy, John Pollina and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Japanese 2021 nationwide survey on complications from spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Observational
  10. Article
  11. Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cathleen C KuoJacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, NY, USA.
Mohamed A R SolimanDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
Alexander O AguirreJacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, NY, USA.
Dennis YoungsSUNY Upstate Medical University, Syracuse, NY, USA.
Marissa KrukJacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, NY, USA.
Ryan M HessDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
Elizabeth M NyabutoDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
Asham KhanDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
Patrick K JowdyDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
John PollinaDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.
Jeffrey P MullinDepartment of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA. jmullin@ubns.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine risk factors increasing susceptibility to early complications (intraoperative and postoperative within 6 weeks) associated with surgery to correct thoracic and lumbar spinal deformity.

methodsWe systematically searched the PubMed and EMBASE databases for studies published between January 1990 and September 2021. Observational studies evaluating predictors of early complications of thoracic and lumbar spinal deformity surgery were included. Pooled odds ratio (OR) or standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated via the random effects model.

resultsFifty-two studies representing 102,432 patients met the inclusion criteria. Statistically significant patient-related risk factors for early complications included neurological comorbidity (OR = 3.45, 95% CI 1.83-6.50), non-ambulatory status (OR = 3.37, 95% CI 1.96-5.77), kidney disease (OR = 2.80, 95% CI 1.80-4.36), American Society of Anesthesiologists score > 2 (OR = 2.23, 95% CI 1.76-2.84), previous spine surgery (OR = 1.98, 95% CI 1.41-2.77), pulmonary comorbidity (OR = 1.94, 95% CI 1.21-3.09), osteoporosis (OR = 1.60, 95% CI 1.17-2.20), cardiovascular diseases (OR = 1.46, 95% CI 1.20-1.78), hypertension (OR = 1.37, 95% CI 1.23-1.52), diabetes mellitus (OR = 1.84, 95% CI 1.30-2.60), preoperative Cobb angle (SMD = 0.43, 95% CI 0.29, 0.57), number of comorbidities (SMD = 0.41, 95% CI 0.12, 0.70), and preoperative lumbar lordotic angle (SMD = - 0.20, 95% CI - 0.35, - 0.06). Statistically significant procedure-related factors were fusion extending to the sacrum or pelvis (OR = 2.53, 95% CI 1.53-4.16), use of osteotomy (OR = 1.60, 95% CI 1.12-2.29), longer operation duration (SMD = 0.72, 95% CI 0.05, 1.40), estimated blood loss (SMD = 0.46, 95% CI 0.07, 0.85), and number of levels fused (SMD = 0.37, 95% CI 0.03, 0.70).

conclusionThese data may contribute to development of a systematic approach aimed at improving quality-of-life and reducing complications in high-risk patients.

Indexed as

Cardiovascular DiseasesHypertensionSpinal FusionDatabases, FactualHumansLumbar VertebraeNeurosurgical ProceduresPostoperative ComplicationsRisk FactorsComplicationsMeta-analysisRisk assessmentRisk factorsSpinal deformity

Identifiers

PMID36611078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.