Evidence map›Paper›PMID 36610669›Full record

ArticleChest2023

Peripheral Airway Dysfunction in Obesity and Obese Asthma.

Anne E Dixon, Matthew E Poynter, Olivia Johnson Garrow, David A Kaminsky, W G Tharp, Jason H T Bates

Open access · greenAbstract read
In one paragraph

Article in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anne E DixonDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT. Electronic address: anne.dixon@uvmhealth.org.
Matthew E PoynterDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
Olivia Johnson GarrowDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
David A KaminskyDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
W G TharpDepartment of Anesthesiology, Larner College of Medicine, University of Vermont, Burlington, VT.
Jason H T BatesDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT.
University of Vermont · US

Funding

Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial FunctionR01HL133920 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, POYNTER, MATTHEW E · 2016 to 2020
$3.9M
Ketone Body Supplementation in Obese AsthmaR01HL142081 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL133920NHLBI NIH HHS R01 HL142081
6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate physiological phenotypes of asthma in obesity. RESEARCH QUESTION: Do physiological responses during bronchoconstriction distinguish different groups of asthma in people with obesity, and also differentiate from responses simply related to obesity? STUDY DESIGN AND

methodsCross-sectional study of people with obesity (31 with asthma and 22 without lung disease). Participants underwent methacholine challenge testing with measurement of spirometry and respiratory system impedance by oscillometry.

resultsParticipants had class III obesity (BMI, 46.7 ± 6.6 kg/m

interpretationPeripheral airway reactivity detected by oscillometry is common in obese control subjects and obese people with asthma. There is a subgroup of obese asthma characterized by significant peripheral airway dysfunction by oscillometry out of proportion to spirometric airway dysfunction. This peripheral dysfunction represents clinically significant respiratory disease not readily assessed by spirometry.

Indexed as

AsthmaAirway ResistanceBronchial Provocation TestsCross-Sectional StudiesFemaleForced Expiratory VolumeHumansMethacholine ChlorideObesityRespiratory SystemSpirometryMethacholine Chlorideimpedancelung functionmethacholineoscillometryspirometry

Identifiers

PMID36610669
PMCPMC10107055
OpenAlexW4313493285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.