Evidence map›Paper›PMID 36610400›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2023

Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates.

Paul T Ranum, Luis Tecedor, Megan S Keiser, Yong Hong Chen, David E Leib, Xueyuan Liu, Beverly L Davidson

Abstract readLetter
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. The rise of cochlear gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. AAV-mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  11. Cochlear Aqueduct Post-Natal Growth: A Computed Tomography Study.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
  12. Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024
    Review
  13. Article
  14. Molecular therapy. Nucleic acids · 2023
    Article
  15. Human cochlear diffusion from the cerebrospinal fluid space with gadolinium contrast.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paul T RanumRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Postdoctoral Training Program in Genomic Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Luis TecedorRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Megan S KeiserRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Yong Hong ChenRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
David E LeibRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Xueyuan LiuRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Beverly L DavidsonRaymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Postdoctoral Training Program in Genomic MedicineT32HG009495 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Katherine L. Nathanson, Bogdan Pasaniuc · 2017 to 2026
$4.2M
NHGRI NIH HHS T32 HG009495
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CochleaGene Transfer TechniquesAnimalsDependovirusGenetic VectorsPrimatesAAVadeno-associated virusAfrican greenauditory hair cellsbene therapycerebrosipinal fluidcochleaCSFgearing lossinner hair cellsmacaquenon-human primate

Identifiers

PMID36610400
PMCPMC10014218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.