Evidence map›Paper›PMID 36610230›Full record

ArticleParkinsonism & related disorders2023

Anosognosia in HD: Comparison of self-report and caregiver ratings with objective performance measures.

Shelby B Hughes, Emma Churchill, Anna Smirnova, Andrew Hall, Braden Culbert, Chase Snell, Brenton A Wright, Paul E Gilbert, Jody Corey-Bloom

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. How Early Does Anosognosia Begin in Huntington's Disease?Movement disorders clinical practice · 2025
    Article
  3. Article
  4. Article
  5. Caffeine Use in Huntington's Disease: A Single Center Survey.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Shelby B HughesDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA; San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: shhughes@health.ucsd.edu.
Emma ChurchillDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA; Department of Psychology, San Diego State University, San Diego, CA, USA.
Anna SmirnovaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Andrew HallDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Braden CulbertDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Chase SnellDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Brenton A WrightDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Paul E GilbertSan Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Department of Psychology, San Diego State University, San Diego, CA, USA.
Jody Corey-BloomDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA; San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
University of California San Diego · USSan Diego State University · USUC San Diego Health System · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
NIA NIH HHS P30 AG062429
6 · The paper itself

Abstract

introductionIndividuals with Huntington's disease (HD) commonly experience anosognosia, a lack of awareness of deficits. Thus, it is important to examine the accuracy of patient vs caregiver ratings on the basis of objective performance-based measures.

methodsThe Anosognosia Scale (AS) was given to 33 patients with manifest HD and their caregivers. The AS consists of 8 items in which individuals rate their global abilities relative to same-aged peers. Scores range from very impaired to excellent. Caregiver and patient ratings were then correlated with objective measures.

resultsCaregivers' evaluations of patients' cognitive and motoric abilities were more highly correlated with objective measures than patients' ratings. Specifically, caregivers' AS item scores were highly correlated with objective measures of walking (Unified Huntington Disease Rating Scale (UHDRS) tandem walking score [r = 0.57, p = .001] vs. patient [r = 0.39, p = .031]); dexterity (UHDRS pronation supination score [r = 0.55, p = .011] vs. patient [r = 0.18, p = .393]); speech (UHDRS dysarthria score [r = 0.55, p = .004] vs. patient [r = 0.03, p = .854]); memory (MoCA score [r = -.45, p = .048] vs. patient [r = -.11, p = .963]); attention (Trails Making Test A score [r = 0.58, p = .004] vs. patient [r = 0.08, p = .686]); and word retrieval (category fluency ([r = -.58, p = .004] vs. patient [r = -.02, p = 1.00]). Moreover, both the UHDRS total motor score (TMS) (F(1,29) = 7.50, p = .010) and the Mini Mental Status Exam (MMSE) (F(1,31) = 5.40, p = .027) were significant predictors of patient levels of anosognosia.

conclusionsOur findings indicate that caregivers may be better able to rate HD patients' cognitive and motor abilities than patients themselves. Both cognitive and motor severity are significant predictors of levels of anosognosia in HD.

Indexed as

AgnosiaHuntington DiseaseCaregiversHumansSelf ReportWalkingAnosognosiaBehaviorCognitionHuntington's diseaseMovement disorders

Identifiers

PMID36610230
PMCPMC9933916
OpenAlexW4313333241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.