Evidence map›Paper›PMID 36610031›Full record

ArticleVeterinary medicine and science2023

Molecular characterization and expression of TGFβRI and TGFβRII and its association with litter size in Tibetan sheep.

Junxia Zhang, Mingming Li, Ruizhe Sun, Na He, Xiaocheng Wen, Xueping Han, Zenghai Luo

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Junxia ZhangCollege of Agriculture and Animal Husbandry, Key Laboratory of Livestock and Poultry Genetics and Breeding on the Qinghai-Tibet Plateau, Ministry of Agriculture and Rural Affairs, Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining, P. R. China.ORCID 0000-0002-5561-0290
Mingming LiCollege of Agriculture and Animal Husbandry, Key Laboratory of Livestock and Poultry Genetics and Breeding on the Qinghai-Tibet Plateau, Ministry of Agriculture and Rural Affairs, Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining, P. R. China.
Ruizhe SunCollege of Agriculture and Animal Husbandry, Key Laboratory of Livestock and Poultry Genetics and Breeding on the Qinghai-Tibet Plateau, Ministry of Agriculture and Rural Affairs, Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining, P. R. China.
Na HeCollege of Agriculture and Animal Husbandry, Key Laboratory of Livestock and Poultry Genetics and Breeding on the Qinghai-Tibet Plateau, Ministry of Agriculture and Rural Affairs, Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining, P. R. China.
Xiaocheng WenCollege of Agriculture and Animal Husbandry, Key Laboratory of Livestock and Poultry Genetics and Breeding on the Qinghai-Tibet Plateau, Ministry of Agriculture and Rural Affairs, Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Qinghai University, Xining, P. R. China.
Xueping HanTechnology Extension Service of Animal Husbandry of Qinghai, Xining, China.
Zenghai LuoTechnology Extension Service of Animal Husbandry of Qinghai, Xining, China.
Qinghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsTransforming growth factor-β (TGF-β) type I receptor (TGFβRI) and type II receptor (TGFβRII) are the members of the TGFβ superfamily, which are potent regulators of cell proliferation and differentiation in many organ systems, and they play key roles in multiple aspects of follicle development.

objectivesWe aimed to explore the characterization, expression analysis of TGFβRI and TGFβRII genes, and the association with litter size in Tibetan sheep.

methodsIn this study, we cloned the complete coding sequences of TGFβRI and TGFβRII genes in Tibetan sheep and analyzed their genomic structures.

resultsThe results showed that percentages of sequences homology of the two proteins in Tibetan sheep were the most similar to Ovis aries (100%), followed by Bos mutus (99%). The RT-qPCR showed that two genes were expressed widely in the different tissues of Tibetan sheep. The TGFβRI expression was the highest in the lung (p < 0.05), followed by the spleen and ovary (p < 0.05). The TGFβRII expression was significantly higher in uterus than that in lung and ovary (p < 0.05). In addition, the χ

conclusionsBased on these preliminary results, we can assume that TGFβ receptors (TGFβRI and TGFβRII) may play an important role in sheep reproduction.

Indexed as

Gene Expression ProfilingLitter SizeReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type IISheepAmino Acid SequenceAnimalsCloning, MolecularEvolution, MolecularFemaleGenetics, PopulationHaplotypesHumansModels, MolecularPolymorphism, Single NucleotideProtein ConformationReceptor, Transforming Growth Factor-beta Type IReceptor, Transforming Growth Factor-beta Type IIgenetic characteristicsTGFβRI and TGFβRII genesTibetan sheep

Identifiers

PMID36610031
PMCPMC10029873
OpenAlexW4313656352

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read61
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.