Evidence map›Paper›PMID 36609882›Full record

ArticleMacromolecular bioscience2023

Zwitterionic Polysulfobetaine Coating and Antiplatelet Liposomes Reduce Fouling in Artificial Lung Circuits.

Kagya Amoako, Rikki Kaufman, Waad A M Haddad, Romario Pusey, Venkata H K Saniesetty, Hao Sun, David Skoog, Keith Cook

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Antifouling Zwitterionic Polymer Coatings for Blood-Bearing Medical Devices.Langmuir : the ACS journal of surfaces and colloids · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kagya AmoakoDepartment of Chemistry and Chemical and Biomedical Engineering, Interim Chair, Mechanical and Industrial Engineering, University of New Haven, West Haven, CT, 06516, USA.ORCID 0000-0002-2150-5214
Rikki KaufmanDepartment of Chemistry and Chemical and Biomedical Engineering, University of New Haven, West Haven, CT, 06516, USA.
Waad A M HaddadDepartment of Chemistry and Chemical and Biomedical Engineering, University of New Haven, West Haven, CT, 06516, USA.
Romario PuseyDepartment of Chemistry and Chemical and Biomedical Engineering, University of New Haven, West Haven, CT, 06516, USA.
Venkata H K SaniesettyDepartment of Chemistry and Chemical and Biomedical Engineering, University of New Haven, West Haven, CT, 06516, USA.
Hao SunDepartment of Chemistry and Chemical and Biomedical Engineering, University of New Haven, West Haven, CT, 06516, USA.
David SkoogAdvanced Respiratory Technologies, LLC, Pittsburgh, PA, 15238, USA.
Keith CookDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
University of New Haven · USAdvanced Materials Corporation (United States) · USCarnegie Mellon University · US

Funding

The Road to Destination Therapy: Optimizing Long-Term Mechanical Cardiopulmonary Support for Pulmonary HypertensionR01HL140231 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BACCHETTA, MATTHEW DOMINIC · 2018 to 2021
$2.7M
NHLBI NIH HHS R01 HL140231NIH HHS 1R01HL140231-01A1
6 · The paper itself

Abstract

The artificial lung has provided life-saving support for pulmonary disease patients and recently afforded patients with severe cases of COVID-19 better prognostic outcomes. While it addresses a critical medical need, reducing the risk of clotting inside the device remains challenging. Herein, a two-step surface coating process of the lung circuit using Zwitterionic polysulfobetaine methacrylate is evaluated for its nonspecific protein antifouling activity. It is hypothesized that similarly applied coatings on materials integrated (IT) or nonintegrated (NIT) into the circuit will yield similar antifouling activity. The effects of human plasma preconditioned with nitric oxide-loaded liposome on platelet (plt) fouling are also evaluated. Fibrinogen antifouling activities in coated fibers are similar in the IT and NIT groups. It however decreases in coated polycarbonate (PC) in the IT group. Also, plt antifouling activity in coated fibers is similar in the IT and NIT groups and is lower in coated PC and Tygon in the IT group compared to the NIT group. Coating process optimization in the IT lung circuit may help address difference in the coating appearance of outer and inner fiber bundle fibers, and the NO-liposome significantly reduces (86%) plt fouling on fibers indicating its potential use for blood anticoagulation.

Indexed as

COVID-19LiposomesAdsorptionBlood PlateletsHumansLungLiposomesantifouling zwitterionic coatingsantiplatelet liposomesextracorporeal membrane oxygenationhuman blood plasmanonspecific protein fouling

Identifiers

PMID36609882
PMCPMC10121813
OpenAlexW4313680469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.