Evidence map›Paper›PMID 36609773›Full record

Trial reportJournal of endocrinological investigation2023

Gender-specific effects of capsiate supplementation on body weight and bone mineral density: a randomized, double-blind, placebo-controlled study in slightly overweight women.

G Salvio, M Petrelli, S Paolini, V Baldini, C Sbaffi, S Basili, A Giordano, G Balercia, S Cinti

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

G SalvioDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
M PetrelliDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
S PaoliniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
V BaldiniDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
C SbaffiDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
S BasiliDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
A GiordanoCenter of Obesity, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
G BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
S CintiCenter of Obesity, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy. saverio.cinti@icloud.com.
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOverweight and obesity are highly prevalent conditions associated with premature morbidity and mortality worldwide. Capsiate, a nonpungent analogue of capsaicin, binds to TRP vanilloid 1 (TRPV1) receptor, which is involved in adipogenesis, and could be effective as a weight-lowering agent.

methodsEighteen slightly overweight women were enrolled in this randomized, double-blind, placebo-controlled study. Nine patients were included in the capsiate intervention group and received 9 mg/day of capsinoids and 9 patients received placebo for 8 weeks. All patients underwent weight and waist circumference assessment before and after treatment. Body composition and bone mineral density (BMD) were also detected by dual-energy X-ray absorptiometry (DXA).

resultsFourteen patients completed the study. The treatment with capsiate or placebo for 8 weeks was not associated with significant changes in weight or waist circumference. After treatment, there was a significant improvement in BMD values measured at the spine in the capsiate group (1.158 vs 1.106 g/cm

conclusionsTreatment with capsiate for 8 weeks led to negligible changes in body weight in a small sample of slightly overweight women, but our findings suggest a potential effect of capsaicin on bone metabolism in humans.

Indexed as

Bone DensityCapsaicinDietary SupplementsDouble-Blind MethodFemaleHumansOverweightCapsaicincapsiateBrown adipose tissueCapsaicinCapsinoidsOsteoporosisSpices

Identifiers

PMID36609773
OpenAlexW4313650669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.