Evidence map›Paper›PMID 36609716›Full record

ReviewInflammopharmacology2023

A cellular and molecular biology-based update for ivermectin against COVID-19: is it effective or non-effective?

Mohsen Nabi-Afjadi, Fatemeh Mohebi, Hamidreza Zalpoor, Fatemeh Aziziyan, Abdullatif Akbari, Hemen Moradi-Sardareh, Elham Bahreini, Amir Mansour Moeini, Hossein Effatpanah

Abstract readReview
In one paragraph

Review in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Topical ivermectin ointment treatment of Demodex blepharitis: a 6-year retrospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Review
  6. Impact of Ivermectin on the Gut Microbial Ecosystem.International journal of molecular sciences · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohsen Nabi-Afjadi *Department of Biochemistry, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran. Mohsennabi66@gmail.com.
Fatemeh Mohebi *Molecular Medicine Research Center, Hormozghan Health Institute, Hormozghan University of Medical Sciences, Bandar Abbas, Iran.
Hamidreza ZalpoorShiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0000-0002-8057-2804
Fatemeh AziziyanDepartment of Biochemistry, Faculty of Biological Sciences, University of Tarbiat Modares, Tehran, Iran.
Abdullatif AkbariNetwork of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Hemen Moradi-SardarehAsadabad School of Medical Science, Hamedan, Asadabad, Iran. hemen.moradi@yahoo.com.ORCID http://orcid.org/0000-0002-5522-4445
Elham BahreiniDepartment of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. elhambahreini@yahoo.com.
Amir Mansour MoeiniDepartment of Internal Medicine, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hossein EffatpanahAsadabad School of Medical Science, Hamedan, Asadabad, Iran.

Funding

Asadabad School of Medical Science 70
6 · The paper itself

Abstract

Despite community vaccination against coronavirus disease 2019 (COVID-19) and reduced mortality, there are still challenges in treatment options for the disease. Due to the continuous mutation of SARS-CoV-2 virus and the emergence of new strains, diversity in the use of existing antiviral drugs to combat the epidemic has become a crucial therapeutic chance. As a broad-spectrum antiparasitic and antiviral drug, ivermectin has traditionally been used to treat many types of disease, including DNA and RNA viral infections. Even so, based on currently available data, it is still controversial that ivermectin can be used as one of the effective antiviral agents to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or not. The aim of this study was to provide comprehensive information on ivermectin, including its safety and efficacy, as well as its adverse effects in the treatment of COVID-19.

Indexed as

COVID-19Antiviral AgentsHumansIvermectinSARS-CoV-2Antiviral AgentsIvermectinCOVID-19FamotidineFavipiravirIvermectinRibavirinSARS-CoV-2

Identifiers

PMID36609716
PMCPMC9823263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.