Evidence map›Paper›PMID 36609683›Full record

ArticleCommunications biology2023

Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression.

Juliana K Choi, Samer A Naffouje, Masahide Goto, Jing Wang, Konstantin Christov, David J Rademacher, Albert Green, Arlene A Stecenko, Ananda M Chakrabarty, Tapas K Das Gupta and 1 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Decoding the power of the microbiome in human health.Frontiers in cellular and infection microbiology · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. The Production of Recombinant Azurin fromInternational journal of molecular sciences · 2025
    Article
  17. Article
  18. Article
  19. Cancers · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Juliana K Choi *Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
Samer A Naffouje *Department of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
Masahide GotoDepartment of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
Jing WangDepartment of Mathematics, Statistics and Computer Science, University of Illinois College of Liberal Arts and Sciences, Chicago, IL, 60607, USA.ORCID 0000-0002-6919-470X
Konstantin ChristovDepartment of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
David J RademacherDepartment of Microbiology and Immunology and Core Imaging Facility, Loyola University Chicago, Maywood, IL, 60153, USA.
Albert GreenDepartment of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
Arlene A StecenkoDivision of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Ananda M ChakrabartyDepartment of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, 60612, USA.
Tapas K Das GuptaDepartment of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA. tkdg@uic.edu.
Tohru YamadaDepartment of Surgery, Division of Surgical Oncology, University of Illinois College of Medicine, Chicago, IL, 60612, USA. tohru@uic.edu.ORCID 0000-0001-6594-3534
University of Illinois Urbana-Champaign · USCleveland Clinic · USEmory University · USIllinois College · USLoyola University Chicago · US

Funding

Development of a New Fluorescent Agent for Intraoperative Image-Guided Breast Cancer SurgeryR01EB023924 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAMADA, TOHRU · 2018 to 2021
$1.4M
Acquisition of a Q-Exactive HF Mass SpectrometerS10OD027016 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2019 to 2019
$600k
MicroRNA Targeted Therapeutic Approach for Pediatric High-Grade GliomaR21CA252370 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAMADA, TOHRU · 2020 to 2020
$411k
NCI NIH HHS R21 CA252370NIBIB NIH HHS R01 EB023924NIH HHS S10 OD027016
6 · The paper itself

Abstract

Microorganisms living at many sites in the human body compose a complex and dynamic community. Accumulating evidence suggests a significant role for microorganisms in cancer, and therapies that incorporate bacteria have been tried in various types of cancer. We previously demonstrated that cupredoxin azurin secreted by the opportunistic pathogen Pseudomonas aeruginosa, enters human cancer cells and induces apoptotic death

Indexed as

AzurinNeoplasmsAnimalsCell Physiological PhenomenaFructose-Bisphosphate AldolaseHumansMicePseudomonas aeruginosaAzurinFructose-Bisphosphate Aldolase

Identifiers

PMID36609683
PMCPMC9823004
OpenAlexW4313597042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.