Evidence map›Paper›PMID 36609456›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs.

Emma E Boxer, JungMin Kim, Brett Dunn, Jason Aoto

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  6. Review
  7. A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  8. Article
  9. Functional Autapses Selectively Form in a Subpopulation of Subicular Pyramidal Cells in Hippocampal Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emma E BoxerUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
JungMin KimUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Brett DunnUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado 80045.
Jason AotoUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 jason.aoto@cuanschutz.edu.ORCID 0000-0003-0568-634X
University of Colorado Anschutz Medical Campus · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Neuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1M
Functional and mechanistic interrogation of alpha neurexin extracellular domainsR01MH116901 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2018 to 2022
$1.9M
Synaptic Dissection of Cell Adhesion Molecule Function within Subicular CircuitsR00MH103531 · NIMH · UNIVERSITY OF COLORADO DENVER · PI AOTO, JASON · 2016 to 2018
$746k
Cell-type and sex-specific organization and neurexin-3 utilization at parvalbumin inhibitory synapses in ventral subiculumF31MH125510 · NIMH · UNIVERSITY OF COLORADO DENVER · PI BOXER, EMMA E · 2021 to 2022
$44k
NIGMS NIH HHS T32 GM007635NIMH NIH HHS F31 MH125510NIMH NIH HHS R00 MH103531NIMH NIH HHS R01 MH116901NINDS NIH HHS T32 NS099042
6 · The paper itself

Abstract

Ventral subiculum (vSUB) is the major output region of ventral hippocampus (vHIPP) and sends major projections to nucleus accumbens medial shell (NAcMS). Hyperactivity of the vSUB-NAcMS circuit is associated with substance use disorders and the modulation of vSUB activity alters drug seeking and drug reinstatement behavior in rodents. However, to the best of our knowledge, the cell type-specific connectivity and synaptic transmission properties of the vSUB-NAcMS circuit have never been directly examined. Instead, previous functional studies have focused on total ventral hippocampal (vHIPP) output to NAcMS without distinguishing vSUB from other subregions of vHIPP, including ventral CA1 (vCA1). Using

Indexed as

CalciumNucleus AccumbensAnimalsFemaleHippocampusMaleMedium Spiny NeuronsMiceReceptors, DopamineCalciumReceptors, Dopaminecalcium-permeablecocaineconnectivityMSNsnucleus accumbensventral subiculum

Identifiers

PMID36609456
PMCPMC9962776
OpenAlexW4313643991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.