Evidence map›Paper›PMID 36609226›Full record

Observational studyBMC anesthesiology2023

Cognitive function in older patients and their stress challenge using different anesthesia regimes: a single center observational study.

Soeren Wagner, Martin Breitkopf, Elena Ahrens, Haobo Ma, Olivia Kuester, Christine Thomas, Christine A F von Arnim, Andreas Walther

2 registry-linked trialsOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02505815 completednot on this map

Neurocognitive Function After Regional and General Anesthesia: a Randomized Control Trial

TypeobservationalSponsorUniversity of Erlangen-Nürnberg Medical SchoolRan2014 to 2016Enrolled80ConditionsNeurocognitive FunctionArmsSurgery, Cortisol Level Measurement, Neurocognitive Testing
NCT07289945 phase3completednot on this mapstarted 2024, after this paper: background citation

A comparative study of desflurane versus sevoflurane in elderly patients: effect on early recovery

TypeinterventionalSponsorHopital Charles NicolleRan2024 to 2025Enrolled81ConditionsEarly Recovery in Elderly Patients, Cognitive FunctionArmsSevoflurane, Desflurane
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Soeren WagnerDepartment of Anesthesiology and Intensive Care, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany. soeren.wagner@tum.de.
Martin BreitkopfDepartment of Anesthesiology and Intensive Care, Katharinenhospital Klinikum Stuttgart, Stuttgart, Germany.
Elena AhrensDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Haobo MaDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Olivia KuesterDepartment of Neurology, Universitaetsklinikum Ulm, Ulm, Germany.
Christine ThomasDepartment of Old Age Psychiatry and Psychotherapy, Klinikum Stuttgart, Krankenhaus Bad Cannstatt, Stuttgart, Germany.
Christine A F von ArnimDepartment of Geriatrics, University of Goettingen Medical School, Goettingen, Germany.
Andreas WaltherDepartment of Anesthesiology and Intensive Care, Katharinenhospital Klinikum Stuttgart, Stuttgart, Germany.
Beth Israel Deaconess Medical Center · USKlinikum Stuttgart · DEHarvard University · USKatharinenhospital · DEUniversity Hospital Ulm · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith increasing age older patients are at higher risk for cognitive decline after surgery. Even tailored anesthesia procedures in older patients remain a high risk for postoperative cognitive disorder. Additional stress derived from anxiety and anesthesia itself can negatively impact postoperative cognitive outcomes. The objective of this study was to evaluate the impact of general versus regional anesthesia on postoperative cognitive disorder and indicators of perioperative stress in elderly undergoing surgery.

methodsIn this single center prospective study between December 2014 and November 2015, 46 patients aged 50 to 85 years undergoing dermatology surgery were enrolled. Patients were stratified by receiving general versus regional nerve anesthesia. On three consecutive days, saliva cortisol levels were analyzed three times per day. Cognitive function was assessed on the day before and the day after surgery using comprehensive neuropsychological testing of multiple cognitive functions including memory, executive function, attention and processing speed.

resultsComparing the regional anesthesia group (RAG, n = 28) with the general anesthesia group (GAG, n = 18) no significant difference in the postoperative cognitive function was observed. However, patients in the GAG had significantly higher postoperative cortisol levels when compared to patients in the RAG. In both groups, a peak of cortisol value was detected on the day of surgery, which was higher in the GAG in comparison to the RAG.

conclusionsWe did not observe a difference in postoperative cognitive function between patients undergoing regional or general anesthesia for dermatology surgery. However, we found lower cortisol level in the RAG. Based on these findings, future studies should investigate alternatives to reduce stress in a general anesthesia setting.

trial registrationClinicalTrials.gov ID: NCT02505815.

Indexed as

Anesthesia, ConductionPostoperative Cognitive ComplicationsAgedAnesthesia, GeneralCognitionHumansHydrocortisonePostoperative ComplicationsProspective StudiesHydrocortisoneCognitive functionCortisolStress

Identifiers

PMID36609226
PMCPMC9817364
OpenAlexW4313640720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.