Evidence map›Paper›PMID 36609223›Full record

ArticleBMC microbiology2023

Comparative activities of ampicillin and teicoplanin against Enterococcus faecalis isolates.

Georgios V Zacharopoulos, Georgios A Manios, Marios Papadakis, Dimitra Koumaki, Sofia Maraki, Dimitrios Kassotakis, Eelco De Bree, Andreas Manios

Open access · goldAbstract read
In one paragraph

Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  7. Exploring Plant-Based Compounds as Alternatives for TargetingInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Georgios V ZacharopoulosDepartment of Surgical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Georgios A ManiosDepartment of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
Marios PapadakisDepartment of Surgery II, Witten/Herdecke University, Heusnerstrasse 40, Postal code, 42283, Witten, Germany. marios_papadakis@yahoo.gr.
Dimitra KoumakiDepartment of Dermatology and Venereology, University Hospital of Heraklion, Heraklion, 71110, Crete, Greece.
Sofia MarakiDepartment of Clinical Microbiology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Dimitrios KassotakisDepartment of Surgical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Eelco De BreeDepartment of Surgical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Andreas ManiosDepartment of Surgical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
University Hospital of Heraklion · GRUniversity of Thessaly · GRWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnterococcus faecalis remains one of the most common pathogens causing infection in surgical patients. Our goal was to evaluate the antibiotic resistance of E. faecalis, causing infections in a surgical clinic, against two antibacterial drugs, ampicillin and teicoplanin. One commonly administered in the past for such infections, ampicillin, and another newer, teicoplanin, which demonstrated exceptionally good efficacy.

methodsData from 1882 isolates were retrieved from the microbiology department database during two 5-year periods. Standard biochemical methods were employed for the identification of the isolates. The prevalence of E. faecalis among patients with clinical evidence of infection in a surgical oncology ward was assessed. Confidence interval (CI) as well as standard error (SE) were calculated. Moreover, the annual incidence of E. faecalis infections in this surgical ward was recorded. The susceptibility of E. faecalis to ampicillin and teicoplanin was studied and compared using Fisher's exact test. RESULTS AND

conclusionResults showed that the incidence of E. faecalis infections in the surgical clinic was increasing. Ampicillin, in the later year period, was not statistically different from teicoplanin in treating E. faecalis infections. Consequently, ampicillin seems currently to be an effective antibiotic against such infections that could be used as empiric therapy.

Indexed as

Enterococcus faecalisTeicoplaninAmpicillinAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsAmpicillinAnti-Bacterial AgentsTeicoplaninAmpicillinAntibiotic resistanceEnterococcus faecalisTeicoplanin

Identifiers

PMID36609223
PMCPMC9817409
OpenAlexW4313648694

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.