ArticleThe Lancet. Planetary health2023
Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis.
Article in The Lancet. Planetary health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 105 citations in OpenAlex.
- Review
- Health effects of air pollution on chronic respiratory diseases.The Korean journal of internal medicine · 2026Review
- The triple-hit hypothesis: exploring pulmonary e-cigarette, PMEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Neighborhood Greenspace Enhances Cardiopulmonary Function in Healthy Older Adults: A Multiomics Analysis from the BAPE Study.Environment & health (Washington, D.C.) · 2026Article
- Rental housing may contribute to racial and ethnic disparities in upper respiratory infections.medRxiv : the preprint server for health sciences · 2026Article
- Upper airway dimensions in adolescents with different craniofacial growth patterns: a retrospective cross-sectional comparison of independent samples from 2005 and 2020.BMC oral health · 2026Article
- Association Between Air Pollutants and Infectious Epiglottitis Incidence: A Observational Study.Health science reports · 2026Article
- Seasonal viruses modify short-term air pollution effects on pediatric wheeze and asthma: a time-series study.Environmental health : a global access science source · 2026Article
- Long-Term Air Pollution Exposure, Plant-based Diet, and Asthma Exacerbations in the Nurses' Health Study II.Annals of the American Thoracic Society · 2026Article
- Indoor air pollution in kindergartens is a stronger predictor of preschool wheezing than household pets and passive smoking.Frontiers in public health · 2026Article
- Airway transcriptome networks for ozone and PMGenome medicine · 2025Article
- The Interlinkages Between Ambient Temperature and Air Pollution in Exacerbating Childhood Asthma: A Time Series Study in Cape Town, South Africa.Children (Basel, Switzerland) · 2025Article
- Associations of Early Life Ambient PMPediatric pulmonology · 2025Article
- Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes.Pediatric research · 2025Article
- Association between prenatal ambient particulate matter and childhood asthma is modified by community safety and child sex.Scientific reports · 2025Article
- Asthma Hospitalizations in Children Before and After COVID-19: Insights from Northern Colombia.Clinics and practice · 2025Article
- Impact of Air Pollution on Health: A Rising Concern in Kathmandu, Nepal.JNMA; journal of the Nepal Medical Association · 2025Article
- Air Quality Index as a Predictor of Respiratory Morbidity in At-Risk Populations.International journal of environmental research and public health · 2025Article
- Ambient Air Pollution Exposure and Mortality in the Pulmonary Hypertension Association Registry.Annals of the American Thoracic Society · 2025Article
- Early-Life Allergen Exposure and Its Influence on Risk of Atopic Disease.The journal of allergy and clinical immunology. In practice · 2025Review
Corrections and comments
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Authors and funding
25 authors at 15 institutions in 1 country.
Funding
Abstract
backgroundAsthma prevalence and severity have markedly increased with urbanisation, and children in low-income urban centres have among the greatest asthma morbidity. Outdoor air pollution has been associated with adverse respiratory effects in children with asthma. However, the mechanisms by which air pollution exposure exacerbates asthma, and how these mechanisms compare with exacerbations induced by respiratory viruses, are poorly understood. We aimed to investigate the associations between regional air pollutant concentrations, respiratory illnesses, lung function, and upper airway transcriptional signatures in children with asthma, with particular focus on asthma exacerbations occurring in the absence of respiratory virus.
methodsWe performed a retrospective analysis of data from the MUPPITS1 cohort and validated our findings in the ICATA cohort. The MUPPITS1 cohort recruited 208 children aged 6-17 years living in urban areas across nine US cities with exacerbation-prone asthma between Oct 7, 2015, and Oct 18, 2016, and monitored them during reported respiratory illnesses. The last MUPPITS1 study visit occurred on Jan 6, 2017. The ICATA cohort recruited 419 participants aged 6-20 years with persistent allergic asthma living in urban sites across eight US cities between Oct 23, 2006, and March 25, 2008, and the last study visit occurred on Dec 30, 2009. We included participants from the MUPPITS1 cohort who reported a respiratory illness at some point during the follow-up and participants from the ICATA cohort who had nasal samples collected during respiratory illness or at a scheduled visit. We used air quality index values and air pollutant concentrations for PM
findingsOf the 208 participants from the MUPPITS1 cohort and 419 participants from the ICATA cohort, 168 participants in the MUPPITS1 cohort (98 male participants and 70 female participants) and 189 participants in the ICATA cohort (115 male participants and 74 female participants) were included in our analysis. We identified that increased air quality index values, driven predominantly by increased PM
interpretationOur findings suggest that air pollution is an important independent risk factor for asthma exacerbations in children living in urban areas and is potentially linked to exacerbations through specific inflammatory pathways in the airway. Further investigation of these potential mechanistic pathways could inform asthma prevention and management approaches.
fundingNational Institutes of Health, National Institute of Allergy and Infectious Diseases.
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