Evidence map›Paper›PMID 36608691›Full record

ArticleCell chemical biology2023

LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens.

Elise Loppinet, Harrison A Besser, Agnele Sylvia Sewa, Fu-Chen Yang, Bana Jabri, Chaitan Khosla

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Structural and mechanistic analysis of CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Celiac disease: mechanisms and emerging therapeutics.Trends in pharmacological sciences · 2023
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Elise LoppinetDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Harrison A BesserDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Agnele Sylvia SewaDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Fu-Chen YangDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Bana JabriDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Chaitan KhoslaDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Chemistry, Stanford University, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA. Electronic address: khosla@stanford.edu.
Stanford University · USStanford Medicine · USUniversity of Chicago · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Role of Transglutaminase 2 in Celiac SprueR01DK063158 · NIDDK · STANFORD UNIVERSITY · PI CHAITAN KHOSLA · 2003 to 2026
$11.2M
Medical Scientist Training ProgramT32GM145402 · NIGMS · STANFORD UNIVERSITY · PI Katrin F. Chua · 2022 to 2026
$10.0M
Gluten peptide presentation in celiac disease: investigating the role of transglutaminase 2 using novel chemical probesF30DK132903 · NIDDK · STANFORD UNIVERSITY · PI BESSER, HARRISON ANTHONY · 2022 to 2023
$80k
NIDDK NIH HHS F30 DK132903NIDDK NIH HHS R01 DK063158NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM145402
6 · The paper itself

Abstract

Celiac disease (CeD) is an autoimmune disorder in which gluten-derived antigens trigger inflammation. Antigenic peptides must undergo site-specific deamidation to be presentable to CD4

Indexed as

Celiac DiseaseGlutensHumansLow Density Lipoprotein Receptor-Related Protein-1PeptidesProtein Processing, Post-TranslationalT-LymphocytesGlutensLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanPeptidesantigen presentationceliac diseaseLRP-1MHC-IItransglutaminase-2α(2)-macroglobulin

Identifiers

PMID36608691
PMCPMC9868102
OpenAlexW4313560974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.