Evidence map›Paper›PMID 36608683›Full record

ArticleAmerican journal of human genetics2023

mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data.

Ang Li, Shouye Liu, Andrew Bakshi, Longda Jiang, Wenhan Chen, Zhili Zheng, Patrick F Sullivan, Peter M Visscher, Naomi R Wray, Jian Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  8. Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  9. Genetic evidence and cross-species functional characterization implicateProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ang LiInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.
Shouye LiuInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.
Andrew BakshiDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Longda JiangNew York Genome Centre, New York, NY, USA.
Wenhan ChenEpigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Zhili ZhengInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Peter M VisscherInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.
Naomi R WrayInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Jian YangSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Jian ZengInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia. Electronic address: j.zeng@uq.edu.au.

Funding

2/2 Genetics at an extreme: an efficient genomic study of individuals with clinically severe major depression receiving ECTR01MH121545 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2019 to 2023
$2.9M
NIMH NIH HHS R01 MH121545
6 · The paper itself

Abstract

Gene-based association tests aggregate multiple SNP-trait associations into sets defined by gene boundaries and are widely used in post-GWAS analysis. A common approach for gene-based tests is to combine SNPs associations by computing the sum of χ

Indexed as

Genome-Wide Association StudyMultifactorial InheritanceGenomicsHumansLinkage DisequilibriumPhenotypePolymorphism, Single Nucleotidegene-based testGWASlinkage disequilibriummasking effectmulti-SNP associationset-based test

Identifiers

PMID36608683
PMCPMC9892780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.