ArticleCell2023
An approximate line attractor in the hypothalamus encodes an aggressive state.
Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
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- Comparative neuroanatomy of emotion expression: from flies to humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Reciprocal connections dynamically build consensus between neocortical areas.Nature neuroscience · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Epineuronal space: an emerging hidden hierarchy bridges neuron and mind space.Cell & bioscience · 2026Review
- A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Selective observation following betrayal shapes the social inference landscape.PLoS computational biology · 2026Article
- Manifolds in the Medial Premotor Cortex During Switching From Attending to Tapping to a Metronome.Annals of the New York Academy of Sciences · 2026Article
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- A deformable attractor manifold organizes human resting-state brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Dynamic Compression Flows for Neuroscience Data.bioRxiv : the preprint server for biology · 2026Article
- Reliable Inference of the Encoding of Task States by Individual Neurons Using Calcium Imaging.eNeuro · 2026Article
- InputDSA : Demixing then comparing recurrent and externally driven dynamics.... International Conference on Learning Representations · 2026Article
- Article
- Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- A line attractor maintains aggressiveness during feeding in "hangry" mice.bioRxiv : the preprint server for biology · 2025Article
- An inspiration-off attractor supports the robust and flexible control of breathing.bioRxiv : the preprint server for biology · 2025Article
- Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025Article
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8 authors.
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Abstract
The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA and VMHvl, respectively. Here, we perform dynamical systems modeling of population neuronal activity in these nuclei during social behaviors. In VMHvl, unsupervised analysis identified a dominant dimension of neural activity with a large time constant (>50 s), generating an approximate line attractor in neural state space. Progression of the neural trajectory along this attractor was correlated with an escalation of agonistic behavior, suggesting that it may encode a scalable state of aggressiveness. Consistent with this, individual differences in the magnitude of the integration dimension time constant were strongly correlated with differences in aggressiveness. In contrast, approximate line attractors were not observed in MPOA during mating; instead, neurons with fast dynamics were tuned to specific actions. Thus, different hypothalamic nuclei employ distinct neural population codes to represent similar social behaviors.
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