Evidence map›Paper›PMID 36608398›Full record

ArticleJournal of neuroimmunology2023

AMPAR autoimmunity: Neurological and oncological accompaniments and co-existing neural autoantibodies.

Jennifer A McCombe, Cecilia Zivelonghi, Nisa Vorasoot, Masoud Majed, Eoin P Flanagan, Divyanshu Dubey, Sean J Pittock, Andrew McKeon, Anastasia Zekeridou

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer A McCombeDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Cecilia ZivelonghiDepartment of Neurology and Stroke Unit, University Hospital of Verona, Verona, Italy.
Nisa VorasootDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Division of Neurology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States of America.
Masoud MajedDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America.
Eoin P FlanaganDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America.
Divyanshu DubeyDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States of America.
Sean J PittockDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States of America.
Andrew McKeonDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States of America.
Anastasia ZekeridouDepartment of Neurology, Mayo Clinic, Rochester, MN, United States of America; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America; Center of MS and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States of America. Electronic address: zekeridou.anastasia@mayo.edu.

Funding

Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep PhenotypingR01NS126227 · NINDS · MAYO CLINIC ROCHESTER · PI Andrew McKeon · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS126227
6 · The paper itself

Abstract

α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) encephalitis is rare but treatable. We reviewed the clinical and autoantibody profiles of 52 AMPAR-IgG-positive patients (median age 48 years [range 12-81]; 38 female) identified at the Mayo Clinic neuroimmunology laboratory. Main presentation was encephalitis; symptoms other than encephalitis associated with co-existing antibodies (p = 0.004). A tumor was found in 33/44; mostly thymoma. Most patients had partial (14/29) or complete (11/29) immunotherapy response. Thirty-one patients had at least one co-existing antibody that predicted thymoma in paraneoplastic patients (p = 0.008). In conclusion, in AMPAR encephalitis co-existing antibodies predict clinical presentation other than encephalitis and thymoma.

Indexed as

EncephalitisThymomaThymus NeoplasmsAdolescentAdultAgedAged, 80 and overAutoantibodiesAutoimmunityChildFemaleHumansMaleMiddle AgedYoung AdultAutoantibodiesEncephalitisParaneoplastic neurological syndromeSmall cell lung cancerThymoma

Identifiers

PMID36608398
PMCPMC9905297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.