Evidence map›Paper›PMID 36608274›Full record

ArticleACS applied materials & interfaces2023

Poly(ethylene glycol)-Norbornene as a Photoclick Bioink for Digital Light Processing 3D Bioprinting.

Min Hee Kim, Chien-Chi Lin

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  11. Lithography-based 3D printing of hydrogels.Nature reviews bioengineering · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Min Hee KimDepartment of Biomedical Engineering, Purdue School of Engineering & Technology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-1428-3991
Chien-Chi LinDepartment of Biomedical Engineering, Purdue School of Engineering & Technology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-4175-8796

Funding

Dynamic Double Network Hydrogel for Generating Pancreatic Organoids from InducedPluripotent Stem CellsR01DK127436 · NIDDK · PURDUE UNIVERSITY · PI LIN, CHIEN-CHI · 2022 to 2025
$1.8M
BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia: Admin SuppR01CA227737 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, CHIEN-CHI · 2019 to 2022
$1.5M
NCI NIH HHS R01 CA227737NIDDK NIH HHS R01 DK127436
6 · The paper itself

Abstract

Digital light processing (DLP) bioprinting is an emerging technology for three-dimensional bioprinting (3DBP) owing to its high printing fidelity, fast fabrication speed, and higher printing resolution. Low-viscosity bioinks such as poly(ethylene glycol) diacrylate (PEGDA) are commonly used for DLP-based bioprinting. However, the cross-linking of PEGDA proceeds via chain-growth photopolymerization that displays significant heterogeneity in cross-linking density. In contrast, step-growth thiol-norbornene photopolymerization is not oxygen inhibited and produces hydrogels with an ideal network structure. The high cytocompatibility and rapid gelation of thiol-norbornene photopolymerization have lent itself to the cross-linking of cell-laden hydrogels but have not been extensively used for DLP bioprinting. In this study, we explored eight-arm PEG-norbornene (PEG8NB) as a bioink/resin for visible light-initiated DLP-based 3DBP. The PEG8NB-based DLP resin showed high printing fidelity and cytocompatibility even without the use of any bioactive motifs and high initial stiffness. In addition, we demonstrated the versatility of the PEGNB resin by printing solid structures as cell culture devices, hollow channels for endothelialization, and microwells for generating cell spheroids. This work not only expands the selection of bioinks for DLP-based 3DBP but also provides a platform for dynamic modification of the bioprinted constructs.

Indexed as

BioprintingTissue EngineeringHydrogelsNorbornanesPolyethylene GlycolsPrinting, Three-DimensionalSulfhydryl CompoundsTissue Scaffolds2-norborneneHydrogelsNorbornanespoly(ethylene glycol)diacrylatePolyethylene GlycolsSulfhydryl Compounds3D printingdigital light processin vitro modelpoly(ethylene glycol)thiol−norbornene click reaction

Identifiers

PMID36608274
PMCPMC10279506

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.