Evidence map›Paper›PMID 36608149›Full record

ArticleScience immunology2023

B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling.

Phillip P Domeier, Ziaur S M Rahman, Steven F Ziegler

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Phillip P DomeierCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA, USA.ORCID 0000-0002-9937-8251
Ziaur S M RahmanMicrobiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0001-8431-9681
Steven F ZieglerCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA, USA.ORCID 0000-0003-0657-5529
Benaroya Research InstitutePennsylvania State University · US

Funding

Regulation of Tfh function in autoimmunity by TSLPR21AI169418 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2022 to 2023
$476k
Regulation of germinal centers by thymic stromal lymphopoietin in mice and humansF32AI154787 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI DOMEIER, PHILLIP P · 2020 to 2022
$206k
NIAID NIH HHS F32 AI154787NIAID NIH HHS R21 AI169418
6 · The paper itself

Abstract

Long-lived and high-affinity antibodies are derived from germinal center (GC) activity, but the cytokines that regulate GC function are still being identified. Here, we show that thymic stromal lymphopoietin (TSLP) signaling regulates the GC and the magnitude of antigen-specific antibody responses. Both GC B cells and T follicular helper (T

Indexed as

B-LymphocytesThymic Stromal LymphopoietinT-LymphocytesCytokinesGerminal CenterReceptors, CytokineSignal TransductionCytokinesReceptors, CytokineThymic Stromal Lymphopoietin

Identifiers

PMID36608149
PMCPMC10162646
OpenAlexW4313706745

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.