Evidence map›Paper›PMID 36607966›Full record

ArticlePloS one2023

Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients.

Kunihiro Ishioka, Sumi Hidaka, Naoki Fujiwara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kunihiro IshiokaKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.ORCID 0000-0001-9129-5075
Sumi HidakaKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Naoki FujiwaraKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Mizuki YamanoKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Yasuhiro MochidaKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Machiko OkaKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Kyoko MaesatoKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Hidekazu MoriyaKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Takayasu OhtakeKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Shuzo KobayashiKidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.
Shonan Kamakura General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesZinc deficiency (Zn < 60 μg/dL) is known to play an important role for vascular calcification. However, little data is available regarding the association between zinc deficiency and aorta stiffness in dialysis patients. Thus, we studied the relationship between zinc deficiency and aorta stiffness in non-diabetic hemodialysis (HD) patients.

methodsOf 150 patients receiving maintenance HD at our hospital, we included 79 non-diabetic HD patients (age: 70±11 years, 49 men) after excluding 71 diabetic HD patients. Zinc deficiency was defined as Zn <60 μg/dL during pre-HD blood sampling. The association between zinc deficiency and aorta stiffness was analyzed. Aorta stiffness was evaluated as brachial-ankle pulse wave velocity (baPWV). Other surrogate markers for cardiovascular complications were also measured.

resultsThe zinc deficiency group (ZD group) included 45 patients (57.0%). Compared to the zinc non-deficiency group (ZND group), patients with ZD group were significantly older, higher levels of CRP and hypoalbuminemia. Moreover, they had significantly higher levels of baPWV, and lower levels of ankle-brachial pressure index (ABI) (p<0.05). After adjusting for hypoalbuminemia, and CRP, multivariate analysis showed that age and zinc level were independent predictors of baPWV.

conclusionThe study suggested that zinc deficiency may be an independent risk factor for aorta stiffness, even after adjusting for malnutrition and inflammation.

Indexed as

HypoalbuminemiaMalnutritionVascular StiffnessAgedAged, 80 and overAnkle Brachial IndexAortaHumansMaleMiddle AgedMineralsPulse Wave AnalysisRenal DialysisRisk FactorsZincMineralsZinc

Identifiers

PMID36607966
PMCPMC9821515
OpenAlexW4313644324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.